Effect of Nigella Sativa on Lipid Profile in Albino Rats

Muhammad Anwar Buriro, Muhammad Tayyab

Abstract


Background: Coronary heart disease is a global health problem. Dyslipidemia is one of its major risk factors. The purpose of this study was to assess the effect of Nigella sativa seeds in the diet on lipid profile in albino rats.

Material and methods: Eighty-four albino rats were divided into six groups. Control groups I, III and V were given; low fat diet with 3% sunflower oil, high fat diet with 20% sunflower oil and high fat diet supplemented with 1% colic acid and 0.5% propylthiouracil as atherogenic elements respectively. The Experimental groups II, IV and VI were given above diets respectively supplemented with Nigella sativa seeds. Lipid profile was estimated at 0, 12 and 24 weeks.

Results: Albino rats fed on low fat diet containing 3% sunflower oil supplemented with Nigella sativa showed significant reduction in TC and LDL cholesterol and rise in HDL cholesterol. Those on high fat diet containing 20% sunflower oil with Nigella sativa seeds showed significant reduction in TG and LDL cholesterol and increase in HDL cholesterol. While in those given high fat diet with 20% sunflower oil, along with 1% cholic acid and 0.5% propylthiouracil with the addition of Nigella sativa, there was significant reduction in TC and LDL cholesterol and rise in HDL cholesterol.

Conclusion: Nigella sativa seeds in the diet has a favorable effect on lipid profile by lowering the triglyceride, total cholesterol and LDL cholesterol and increasing the HDL cholesterol in albino rats.


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