IMPACT OF PREEMPTIVE ANALGESIC REGIME ON THE RATS’ ANESTHETIC RECOVERY PERIOD IN SOMATIC PAIN MODEL

Saima Mumtaz Khattak; Najma Baseer; Syed Hamid Habib; Nazish Waheed; Saima Saleem; Sana Malik

doi:10.46903/gjms/21.04.1422

IMPACT OF PREEMPTIVE ANALGESIC REGIME ON THE RATS’ ANESTHETIC RECOVERY PERIOD IN SOMATIC PAIN MODEL

Saima Mumtaz Khattak, Najma Baseer, Syed Hamid Habib, Nazish Waheed, Saima Saleem, Sana Malik

Abstract

Background: Preemptive analgesia refers to the beginning of an analgesic intervention to block peripheral and central nociception before the noxious stimuli manifests. The aim of this study was to evaluate the effectiveness of preemptive regime on smooth recovery of rat undergoing somatic surgical pain model.

Materials & Methods: This Experiment lab based study was conducted at Khyber Medical University Peshawar for one year from January 2022 to January 2023. Thirty five female Sprague-Dawley rats were divided into five distinct research groups, with each group consisting of seven rats. Group A treated with tramadol+lidocain, while group B experienced the administration of buprenorphine+lidocain before surgery. On the other hand, group C had received only saline injections. In order to simulate a realistic minor surgical scenario, each group underwent a lower transverse skin incision right above the pubic symphysis under general anesthesia. Meanwhile, the sham groups, D and E, were treated with injections of tramadol+lidocain and buprenorphine+lidocain respectively, without surgery but following the protocol of general anesthesia.

Results: The implementation of preemptive therapy with either tramadol or buprenorphine significantly shortened the time it took for recovery from the anesthesia (p <0.001), Furthermore, the time for the pedal withdrawal reflex and righting reflex return was significantly reduced compared to the saline group (p <0.001 for both measures). These improvements in recovery by preemptive groups were comparable to those observed in the sham group, with no significant differences observed (p ≥0.05).

Conclusion: The implementation of a preemptive regime significantly reduced the recovery period and accelerated the overall recovery process in the somatic surgical pain model.

Keywords

Preemptive regime; Skin Incision; postoperative pain; recovery from anesthesia; pedal withdrawal reflex; righting reflex.

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DOI: https://doi.org/10.46903/gjms/21.04.1422