IMPACT OF PHYSICAL FITNESS SCORES AND ITS ASSOCIATION WITH INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN HEALTHY INDIVIDUALS AND PATIENTS WITH TYPE 2 DIABETES MELLITUS

Syed Shahid Habib; Thamir Al-khlaiwi; Syed Hamid Habib; Syed Mohammad Habib; Syed AbuBakar Habib; Huthayfah Al-khliwi

doi:10.46903/gjms/22.04.1455

IMPACT OF PHYSICAL FITNESS SCORES AND ITS ASSOCIATION WITH INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN HEALTHY INDIVIDUALS AND PATIENTS WITH TYPE 2 DIABETES MELLITUS

Syed Shahid Habib, Thamir Al-khlaiwi, Syed Hamid Habib, Syed Mohammad Habib, Syed AbuBakar Habib, Huthayfah Al-khliwi

Abstract

Background: Whether physical fitness score has a correlation with any endothelial dysfunction players needs to be evaluated. This study aimed to assess and compare Fitness Scores of Type 2 Diabetes Mellitus (T2DM) patients with healthy individuals and their relationship to Inducible Nitric Oxide Synthase.

Materials & Methods: A cross sectional study conducted at department of Physiology in 198 subjects. Subjects were grouped into Group1: control (n=88), Group 2: T2DM (n=110). Physical fitness score parameters and serum iNOS was compared between different groups.

Results: Waist to hip ratio (WHR) is significantly different between control group (0.92±0.15) and DM group (1.0±0.08) with a p value= 0.00. BMI is also significantly different between the two groups (control: 27.8±5.0, DM: 29.4±4.9 p= 0.02). In addition, fat mass is significantly different between the two group (control: 23.4±8.9, DM: 26.4±10.1, p=0.02) and % fat (control: 29.3±7.7, DM: 32.5±10.8, p=0.01). eNOS is also significantly different between the two groups (control: 112.9±47.5, DM: 86.4±47.3, p=0.00) while iNOS is not significantly different (Control: 25.5±15.4, DM: 27.2±24.1, p=0.55). There is no significant difference in fitness score between control group (69.1±9.9) and DM group (68.2±7.7) with p=0.49. Linear regression analysis is performed to evaluate the association of iNOS as the dependent variable with fitness score as predictors. Linear regression analysis showed a significant negative association of iNOS with fitness score (r=-0.386, p<.001) for all cases, (r=-0.427, p<.001) for control group, and (r=-0.365, p<.001) for diabetes mellitus group.

Conclusions & recommendations: Our findings address the negative correlation between iNOS and fitness score in healthy and DM patients. It reveals the decrease of iNOS as fitness score increases. Fitness score can be used as a predictor of cardiovascular prognosis in diabetic patients. Further and extensive studies are needed in this area to confirm the findings.

Keywords

Type 2 Diabetes Mellitus; Fitness score; iNOS

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DOI: https://doi.org/10.46903/gjms/22.04.1455