BONE HEALING EFFECT OF ZIZIPHUS HONEY ON HUMAN TOOTH EXTRACTION SOCKETS: A RADIOGRAPHIC EVALUATION

Momina Khalid; Asad Mahmood; Fatima Ikram; Omair Anjum; Muhammad Mobin Riaz; Usman Manzoor Warraich

doi:10.46903/gjms/22.04.1618

BONE HEALING EFFECT OF ZIZIPHUS HONEY ON HUMAN TOOTH EXTRACTION SOCKETS: A RADIOGRAPHIC EVALUATION

Momina Khalid, Asad Mahmood, Fatima Ikram, Omair Anjum, Muhammad Mobin Riaz, Usman Manzoor Warraich

Abstract

Background: Tooth extractions are very common in Pakistan nowadays due to various causes such as dental caries, periodontitis, orthodontic purposes, and trauma due to accidents. The objective of the study is to radiographically assess the effect of Ziziphus honey on bone healing of the extracted tooth sockets in humans.

Materials & Methods: The study design was a randomized controlled trial using a Simple random sampling technique which was conducted in the Dental section of Lahore General Hospital, Lahore for the duration of 12 months from January 2020 to December 2020. A total number of 30 participants were divided randomly into an experimental group and a control group with 15 participants in each group. The tooth extractions were done in both groups, and Ziziphus honey was administered in the experimental group. Relative bone density (RBD) was measured on periapical radiographs taken on days 3, 21, and 40 in both groups. The results were interpreted with the help of Image J software®.

Results: The mean difference of 0.003, 0.091, and 0.139 in grey values of RBD was observed in the control and experimental group on days 3, 21, and 40 respectively. A statistically significant difference was observed (p-value <0.001) in the value of RBD at days 21 and 40 of the experimental and control groups.

Conclusion: The increased value of RBD in the experimental group suggest14s better bone healing as compared to the control group. Therefore, Ziziphus honey is a type of honey that can be used as an adjunct to expedite the healing of bone after the extraction of a tooth.

Keywords

Bone density; Healing; Honey; Radiographic; Tooth sockets; Ziziphus;

Full Text:

PDF

References

Ullah MA, Islam SU, Hussain F IM. Factors causing tooth extraction among patients visiting DHQ hospitals DIR Lower and Chitral KPK Pakistan. JWMIPT. 2022;2(2):28-31. Available from: https://www.jwmipt.org.pk/index.php/JWMIPT/article/view/44/25

Fathima T, Santhosh Kumar MP. Evaluation of quality of life following dental extraction. J Adv Pharm Technol Res. 2022;13(5):102-7. https://doi.org/10.4103/japtr.japtr_361_22

Sridhar M, Tiwari RV, Painam R, Somuri AV, Thumpala VK. Factors influencing dental extraction. J Oral Med Oral Surg Oral Pathol Oral Radiol. 2017;3(4):187-9. https://doi.org/10.18231/2395-6194.2017.0045

Daigo Y, Daigo E, Fukuoka H, Fukuoka N, Ishikawa M, Takahashi K. Wound healing and cell dynamics including mesenchymal and dental pulp stem cells induced by photobiomodulation therapy: An example of socket-preserving effects after tooth extraction in rats and a literature review. Int J Mol Sci. 2020;21(18):1-16. https://doi.org/10.3390/ijms21186850

Uchiyama Y, Sumi T, Marutani K, et al. Neurofibromatosis type 1 in the mandible. Ann Maxillofac Surg. 2018;8(1):121-3. https://doi.org/10.4103/ams.ams_135_17

Gomes P de S, Daugela P, Poskevicius L, Mariano L, Fernandes MH. Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: A focused review. J Oral Maxillofac Res. 2019;10(3):1-18. https://doi.org/10.5037/jomr.2019.10302

Rues S, Schmitter M, Kappel S, Sonntag R, Kretzer JP, Nadorf J. Effect of bone quality and quantity on the primary stability of dental implants in a simulated bicortical placement. Clin Oral Investig. 2021;25(3):1265-72. https://doi.org/10.1007/s00784-020-03432-z

Di Stefano DA, Arosio P, Capparè P, Barbon S, Gherlone EF. Stability of dental implants and thickness of cortical bone: Clinical research and future perspectives. A systematic review. Materials (Basel). 2021;14(23):1-21. https://doi.org/10.3390/ma14237183

Hegazi AG, Al Guthami FM, Ramadan MFA, Al Gethami AFM, Craig AM, Serrano S. Characterization of Sidr (Ziziphus spp.) honey from different geographical origins. Appl Sci. 2022;12(18):1-11. https://doi.org/10.3390/app12189295

Ekhtelat M, Ravaji K, Parvari M. Effect of Iranian Ziziphus honey on growth of some foodborne pathogens. J Nat Sci Biol Med. 2016;7(1):54-7. https://doi.org/10.4103/0976-9668.175069

Khan ZA, Prabhu N, Ahmed N, et al. A comparative study to evaluate the effect of honey and zinc oxide eugenol dressing for the treatment of dry socket: A double-blind randomized controlled trial. Appl Sci. 2022;12(1):1-9. https://doi.org/10.3390/app12010006

Wijaya B. Benefits of honey extract against wound healing. Eureka Herba Indones. 2021;3(2):169-73. https://doi.org/10.37275/ehi.v3i2.51

Ilyas MS, Fahim A, Awan U, et al. Effect of honey on healing of extracted tooth socket of albino Wistar rats. Int Med J. 2015;22(5):422-5.

Tu SJ, Wang SP, Cheng FC, Chen YJ. Extraction of gray-scale intensity distributions from micro-computed tomography imaging for femoral cortical bone differentiation between low-magnesium and normal diets in a laboratory mouse model. Sci Rep. 2019;9(1):1-11. https://doi.org/10.1038/s41598-019-44610-8

M G. Evaluation of ImageJ for relative bone density measurement and clinical application. J Oral Heal Craniofacial Sci. 2016;1(1):12-21. https://doi.org/10.29328/journal.johcs.1001002

Duangthip D, Chu CH. Challenges in oral hygiene and oral health policy. Front Oral Heal. 2020;1:1-4. https://doi.org/10.3389/froh.2020.575428

Mittal Y, Jindal G, Garg S. Bone manipulation procedures in dental implants. Indian J Dent. 2016;7(2):86. https://doi.org/10.4103/0975-962X.184650

Elayah SA, Younis H, Cui H, et al. Alveolar ridge preservation in post-extraction sockets using concentrated growth factors: A split-mouth, randomized, controlled clinical trial. Front Endocrinol (Lausanne). 2023;14:1-9. https://doi.org/10.3389/fendo.2023.1163696

Vieira AE, Repeke CE, De Barros Ferreira S, et al. Intramembranous bone healing process subsequent to tooth extraction in mice: Micro-computed tomography, histomorphometric, and molecular characterization. PLoS One. 2015;10(5):1-22. https://doi.org/10.1371/journal.pone.0128021

Kamaruzzaman MA, Chin KY, Mohd Ramli ES. A review of potential beneficial effects of honey on bone health. Evid Based Complement Alternat Med. 2019;2019:1-11. https://doi.org/10.1155/2019/8543618

Martinotti S, Ranzato E. Honey, wound repair, and regenerative medicine. J Funct Biomater. 2018;9(2):1-12. https://doi.org/10.3390/jfb9020034

Arango-Ospina M, Lasch K, Weidinger J, Boccaccini AR. Manuka honey and zein coatings impart bioactive glass bone tissue scaffolds antibacterial properties and superior mechanical properties. Front Mater. 2021;7:1-12. https://doi.org/10.3389/fmats.2020.610889

Ahmed ASAA, Eltregy S, Kandil MI. Honey dressing: A missed way for orthopedic wound care. Int Orthop. 2022;46(11):2483-91. https://doi.org/10.1007/s00264-022-05540-9

Cesur E, Bayrak S, Kursun-Çakmak ES, Arslan C, Köklü A, Orhan K. Evaluating the effects of functional orthodontic treatment on mandibular osseous structure using fractal dimension analysis of dental panoramic radiographs. Angle Orthod. 2020;90(6):783-93. https://doi.org/10.2319/012020-39.1

Schroeder AB, Dobson ETA, Rueden CT, Tomancak P, Jug F, Eliceiri KW. The ImageJ ecosystem: Open-source software for image visualization, processing, and analysis. Protein Sci. 2021;30(1):234-49. https://doi.org/10.1002/pro.3993

DOI: https://doi.org/10.46903/gjms/22.04.1618