LITHIUM INFLUENCE ON INORGANIC COMPONENT OF DEVELOPING DENTAL TISSUES IN PREGNANCY

Shakila Nazir; Arsalan Mirza

doi:10.46903/gjms/23.1.Special.1623

LITHIUM INFLUENCE ON INORGANIC COMPONENT OF DEVELOPING DENTAL TISSUES IN PREGNANCY

Shakila Nazir, Arsalan Mirza

Abstract

Background: Teratogenicity of human dentition may cause aesthetic complications. Deformed enamel of teeth is generally vulnerable to carious lesions and sensitivity of dentition. The contemporary study was initiated to consider the effect on inorganic component in the developing teeth of newborn babies when Lithium was ingested during pregnancy.

Materials & Methods: In this study, female rabbits were taken as mammalian model treated with lithium, their off springs were used to evaluate the teratogenicity of teeth. Quantitative analysis of inorganic component was done in three types of teeth. The experimentation was piloted by means of scanning electron microscope and energy dispersive X-ray spectroscopy (SEM-EDX).

Results: Ample disparities were perceived between the samples of control and the treatment group, though conferring the consequences that incisors and the molars seemed appealingly and operationally affected teeth.

Conclusion: Significant results could not be achieved; however, it is mandatory that the medication should hence be taken by doctor’s advice, especially in the course of pregnancy, avoiding the unfortunate effects on the newborn’s teeth.

Keywords

Defects; Dentition; Developmental; Female; Lithium; Rabbits.

Full Text:

PDF

References

Poels P, Bijma H, Galbally M. Lithium during pregnancy and after delivery: a review. Int J Bipolar Disord. 2018;6:26. https://doi.org/10.1186/s40345-018-0135-7

McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR. Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 2012;379(9817):721-8. https://doi.org/10.1016/S0140-6736(11)61516-X

Da Silva V, Trevisan L, Michels A, Luiz S, Reis L, Brancher J, et al. Effect of the chronic use of lithium carbonate on induced tooth movement in Wistar rats. PLoS One. 2016;11(8):e0160400. https://doi.org/10.1371/journal.pone.0160400

Ishimoto K, Hayano S, Yanagita T, Kurosaka H, Kawanabe N, Itoh S, et al. Topical application of lithium chloride on the pulp induces dentin regeneration. PLoS One. 2015;10(3):e0121938. https://doi.org/10.1371/journal.pone.0121938

Kagioka T, Itoh S, Hue M. Lithium carbonate accelerates the healing of apical periodontitis. Sci Rep. 2023;13:7886. https://doi.org/10.1038/s41598-023-34700-z

Hallmann L, Ulmer P, Kern M. Effect of microstructure on the mechanical properties of lithium disilicate glass-ceramics. J Mech Behav Biomed Mater. 2018;82:355-70. https://doi.org/10.1016/j.jmbbm.2018.02.032

Duarte PM, Miranda TS, Marins LM, Da Silva JRB, De Souza F, De Vasconcelos B, et al. Lithium chloride stimulates bone formation in extraction socket repair in rats. Oral Maxillofac Surg. 2022;15. https://doi.org/10.1007/s10006-022-01124-4

Duarte PM, Miranda TS, Marins LM, Perez EG, Copes LG, Tonietto CB, et al. Systemic lithium chloride administration improves tooth extraction wound healing in estrogen-deficient rats. Braz Dent J. 2020;31(6):640-9. https://doi.org/10.1590/0103-6440202003595

Eren I, Yildiz M, Civi I. The effects of lithium treatment on bone mineral density in bipolar patients. Neurol Psychiatry Brain Res. 2006;13:175-80. https://doi.org/10.1016/S0924-977X(03)91885-2

Wadke A, Kommuri K, Talluri S, Kalladka M, Kalladka G, Khan J. Effect of lithium on orthodontic tooth movement: a systematic review of animal studies. Turk J Orthod. 2024;37(1):63-71. https://doi.org/10.4274/TurkJOrthod.2023.2022.149

Fotiadou C, Manhart J, Diegritz C, Folwaczny M, Hickel R, Frasheri I. Longevity of lithium disilicate indirect restorations in posterior teeth prepared by undergraduate students: a retrospective study up to 8.5 years. J Dent. 2021;105:103569. https://doi.org/10.1016/j.jdent.2020.103569

Eduardo P, Simões A, De Freitas PM, Arana V, Nicolau J, Gentil V. Dentin decalcification during lithium treatment: case report. Spec Care Dentist. 2013;33(2):91-5. https://doi.org/10.1111/scd.12000

Koren G. Special aspects of perinatal & pediatric pharmacology. In: Basic and Clinical Pharmacology. 10th ed. USA: McGraw-Hill; 2007. p. 971-82.

Shakila N, Naeem H, Masood A, Naema N. SEM-EDX analysis for surface aberrations of neonate's teeth influenced by the use of lithium in pregnancy. World J Dent. 2011;2(2):105-10. https://doi.org/10.5005/jp-journals-10015-1065

Wong SK, Chin K-Y, Ima-Nirwana S. The skeletal-protecting action and mechanisms of action for mood-stabilizing drug lithium chloride: current evidence and future potential research areas. Front Pharmacol. 2020;11:430. https://doi.org/10.3389/fphar.2020.00430

Da Silva V, Trevisan L, Michels A, Luiz ST, Reis L, Brancher J, et al. Effect of the chronic use of lithium carbonate on induced tooth movement in Wistar rats. PLoS One. 2016;11(8):e0160400. https://doi.org/10.1371/journal.pone.0160400

Kiełczykowska M, Musik I, Hordyjewska A, Boguszewska A, Lewandowska A, Pasternak K. Oral administration of lithium increases tissue magnesium contents but not plasma magnesium level in rats. Pharmacol Rep. 2007;59(3):291-5. PMID: 17652829.

Parkin GM, McCarthy MJ, Thein SH, Piccerillo HL, Warikoo N, Granger DA, et al. Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model. Bipolar Disord. 2021;23(7):679-88. https://doi.org/10.1111/bdi.13128

Sapir S. Considerations in orthodontic bracket adhesion to hypomineralized enamel. In: Naretto S, editor. Principles in Contemporary Orthodontics. InTech; 2011. https://doi.org/10.5772/22252

Talebian R, Jafari F, Dehpour AR, Gruber R. Effects of lithium chloride and nitric oxide inhibitor on orthodontic tooth movement in the rat. Appl Sci. 2021;11(8):3607. https://doi.org/10.3390/app11083607

Huang L, Yin X, Chen J, Liu R, Xiao X, Hu Z, et al. Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy. Bioact Mater. 2021;6(10):3074-84. https://doi.org/10.1016/j.bioactmat.2021.02.015

Dai Q, Zhou S, Zhang P, Ma X, Ha N, Yang X, et al. Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats. Sci Rep. 2017;7(1):3906. https://doi.org/10.1038/s41598-017-04422-0

DOI: https://doi.org/10.46903/gjms/23.1.Special.1623