MEMBRANE LIPID-ESTROGEN INTERACTION AND MANAGEMENT OF MEDICAL DISORDERS: BIOPHYSICAL MEDICINE

Zahir Hussain

doi:10.46903/gjms/23.1.Special.1733

MEMBRANE LIPID-ESTROGEN INTERACTION AND MANAGEMENT OF MEDICAL DISORDERS: BIOPHYSICAL MEDICINE

Zahir Hussain

Abstract

Estradiol-17beta (E2) is an important gonadosteroid present in large concentration in women and in low levels in men, but it is important for both women and men in various reproductive and non-reproductive functions. Information in the present article is provided about the estrogen-membrane interaction and biophysical mechanisms of drug interaction. Role of membrane lipid- estrogen interaction in various diseases and drug interaction has been described for: health and environmental issues, cytotoxicity, human cell damage by 17 α-ethinylestradiol (EE2) on fluid lipid monolayers, cerebral aneurysms, estrogen signaling and a variety of other aspects. The therapeutic role of the interactions of estrogenic drugs with membrane lipids have been emphasized for: anticancer therapy, breast cancer and hormone dependent tumors, E2-HDL (estradiol-high density lipoprotein)-targeted drug therapies, genistein for treatment of cancer, chlorpromazine and anticancer activity of tamoxifen, membrane disruptions and alpha-tocopherol. Hopefully the future studies would provide further information for physiological, physicochemical and pharmaceutical aspects for better management of diseases and advancement of membrane interaction related studies. The future studies in biophysical medicine may bring a revolution for management of membrane interaction associated diseases and interpretation of the processes at biophysical level.

Keywords

Drug interaction; Estrogen; Lipid; Membrane; Membrane lipid-estrogen.

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References

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DOI: https://doi.org/10.46903/gjms/23.1.Special.1733