PREPARATION AND EVALUATION OF IBUPROFEN  NANOSUSPENSION FOR SOLUBILITY  ENHANCEMENT

Fatimah Mohammed Hussein wais; Areej W. Alhagiesa; Malath Hatif Oudah

doi:10.46903/gjms/23.1.Special.1763

PREPARATION AND EVALUATION OF IBUPROFEN NANOSUSPENSION FOR SOLUBILITY ENHANCEMENT

Fatimah Mohammed Hussein wais, Areej W. Alhagiesa, Malath Hatif Oudah

Abstract

Background: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) having poor water solubility and high permeability. The study aimed to prepare, characterize, and evaluate ibuprofen nanosuspensions to enhance its solubility and dissolution rate.

Materials & Methods: This was an experimental and laboratory-based study. Nanosuspensions of ibuprofen were formulated using three different polymers-PVP K30, Poloxamer 188, and HPMC E50-at various drug-to-polymer ratios (1:1, 1:2, 1:3). The study was conducted in a controlled laboratory environment, typically in a pharmaceutical or chemical research laboratory equipped with instruments like particle size analyzers, scanning electron microscopes, and dissolution apparatus. The formulation and characterization experiments were performed in compliance with standard protocols for nanoparticle formulation and pharmaceutical analysis

Results: All ibuprofen nanosuspensions were within the nano size range (123-564.5 nm), with the smallest particle size (123 nm) observed for PVP K30 at a 1:1 ratio. The PDI ranged from 0.008 to 0.071, and the specific surface area (SSA) ranged from 18.6 to 3.39 m²/g. Saturated solubility of ibuprofen increased by approximately six-fold compared to the pure drug. Entrapment efficiency ranged from 85% to 97%, while the dissolution rate showed a significant improvement, with 98% of the drug released within 15 minutes, compared to 25% release from pure ibuprofen in the same period.

Conclusion: The solvent- Anti-solvent technique is effective for producing ibuprofen Nano-suspensions, significantly enhancing the solubility and dissolution rate of the drug. This formulation approach holds promise for improving the bioavailability of poorly water-soluble drugs like ibuprofen.

Keywords

Dissolution rate; Ibuprofen; NSAID; Nanosuspensions; Polymers; Solvent anti-solvent technique.

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DOI: https://doi.org/10.46903/gjms/23.1.Special.1763