DETECTION OF ATRIAL FIBRILLATION IN PATIENTS WITH COMPLETE HEART BLOCK TREATED WITH DIFFERENT MODES OF PACEMAKER

Hussein Murad Muhamad

Abstract


Background: Atrial fibrillation (AF) and complete heart block (CHB) are significant cardiac conditions often managed with pacemaker implantation. Pacemaker mode may influence the detection and incidence of AF, a common and potentially severe complication in patients with CHB. This study evaluated the association between pacemaker mode (dual-chamber DDD vs. single-chamber VVI) and the incidence of AF in patients with CHB.

Materials & methods: A cross-sectional study was conducted among 114 patients with CHB who received either DDD or VVI pacemakers at the Ibn Al-Bittar Specialized Center for Cardiac Surgery and Al-Nasiriyah Heart Center between December 2015 and April 2016. Demographic and clinical data, including pacemaker type, duration of implantation, and comorbidities, were collected from medical records and structured interviews. AF incidence was assessed using electrocardiography (ECG) and pacemaker interrogation data. Statistical analysis was performed using chi-square and Fisher’s exact tests, with a p-value < 0.05 considered significant.

Results: Among the 114 patients (56 DDD, 58 VVI), 14% (n=16) developed AF. AF incidence was significantly higher in patients with VVI pacemakers (21%) compared to those with DDD pacemakers (7%) (p-value=0.034). No significant differences in AF incidence were observed between pacemaker modes based on gender, age, or the presence of comorbidities such as hypertension, diabetes, or smoking history (p-value>0.05).

Conclusion: In summary, while DDD pacemakers may offer a protective effect against AF compared to VVI pacemakers, this study underscores the complexity of AF management in patients with CHB, indicating that a multifaceted approach is necessary to optimize outcomes.


Keywords


Atrial fibrillation, Complete heart block, Mode of pacemaker

Full Text:

PDF

References


Nasab MRS, Dehghani MR, Taherioun M, Rostamzadeh A. Intracardiac atrial signal amplitude in congenital and acquired complete heart block. Indian Pacing Electrophysiol J. 2010;10(10):447–53.

Bode D, Pronto JRD, Schiattarella GG, Voigt N. Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications. Nat Rev Cardiol. 2024;21(10):682–700.

Bencivenga L, Komici K, Nocella P, Grieco FV, Spezzano A, Puzone B, et al. Atrial fibrillation in the elderly: a risk factor beyond stroke. Ageing Res Rev. 2020;61:101092.

Ata F. Atrioventricular block in patients with hyperthyroidism: a narrative review. J Int Med Res. 2024;52(1):3000605231223040.

Trivedi PM, Arnold P, Shah A, Qureshi AM. Anesthesia for the Cardiac Catheterization Laboratory. In: Anesthesia for Congenital Heart Disease. 2023. p. 890–933. https://doi.org/10.1002/9781119791690.ch34

Edwin F, Aniteye E, Tettey M, Sereboe L, Kotei D, Tamatey M, et al. Permanent complete heart block following surgical correction of congenital heart disease. Ghana Med J. 2010;44(3):109–14.

Edafe E, Odia J, Akpa M, Dodiyi-Manual S, Oye H, Agadah Z. Experience with cardiac pacing in the Nigerian Delta region. Niger J Cardiol. 2020;17(2):136. https://doi.org/10.4103/njc.njc_28_19

Kalahasty G, Ellenbogen K. The role of pacemakers in the management of patients with atrial fibrillation. Med Clin North Am. 2008;92(1):161–78, xi–xii.

Chu SY, Jiang J, Wang YL, Sheng QH, Zhou J, Ding YS. Pacemaker-detected atrial fibrillation burden and risk of ischemic stroke or thromboembolic events-A cohort study. Heart Lung. 2020;49(1):66–72.

Bolanos R, Selzman KA, Jantac L, Stouffer GA. Hemodynamics of arrhythmias and pacemakers. In: Cardiovascular Hemodynamics for the Clinician: Second Edition. 2016. p. 321–40. https://doi.org/10.1002/9781119066491.ch27

Pollak WM, Simmons JD, Interian AJ, Atapattu SA, Castellanos A, Myerburg RJ, et al. Clinical utility of intraatrial pacemaker stored electrograms to diagnose atrial fibrillation and flutter. Pacing Clin Electrophysiol. 2001;24(4 Pt 1):424–9.

Wan D, Andrade J, Laksman Z. Thromboembolic risk stratification in atrial fibrillation-beyond clinical risk scores. Rev Cardiovasc Med. 2021;22(2):353–63.

Sperzel J, Hamm CW, Hain A. Over- and undersensing—pitfalls of arrhythmia detection with implantable devices and wearables. Herzschrittmachertherapie + Elektrophysiologie. 2020;31(3):273–87. https://doi.org/10.1007/s00399-020-00710-x

Kreimer F, Gotzmann M. Pacemaker-induced atrial fibrillation reconsidered—associations with different pacing sites and prevention approaches. Front Cardiovasc Med. 2024;11. https://doi.org/10.3389/fcvm.2024.1412283

Said S, Cooper CJ, Alkhateeb H, Gosavi S, Dwivedi A, Onate E, et al. Incidence of new onset atrial fibrillation in patients with permanent pacemakers and the relation to the pacing mode. Med Sci Monit Int Med J Exp Clin Res. 2014;20:268–73.

Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL, et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003;107(23):2932–7.

Majewski J, Lelakowski J. [Incidence of atrial fibrillation in paced patients with complete atrioventricular block]. Przegl Lek. 2000;57(7–8):386–8.

Allessie MA, Boyden PA, Camm AJ, Kléber AG, Lab MJ, Legato MJ, et al. Pathophysiology and prevention of atrial fibrillation. Circulation. 2001;103(5):769–77.

Berglund H, Nishioka T, Hackner E, Kim CJ, Luo H, Fontana G, et al. Ventricular pacing: a cause of reversible severe mitral regurgitation. Am Heart J. 1996;131(5):1035–7.

Cannan CR, Higano ST, Holmes DRJ. Pacemaker induced mitral regurgitation: an alternative form of pacemaker syndrome. Pacing Clin Electrophysiol. 1997;20(3 Pt 1):735–8.

Amitzur G, Manor D, Pressman A, Adam D, Hammerman H, Shofti R, et al. Modulation of the arterial coronary blood flow by asynchronous activation with ventricular pacing. Pacing Clin Electrophysiol. 1995;18(4 Pt 1):697–710.

Ishikawa T, Sumita S, Kikuchi M, Satoh S, Terada K, Kuji N. Diastolic mitral regurgitation when the heart rate is normalised by ventricular pacing. Eur J Card Pacing Electrophysiol. 1996;6:23–7.

Jordaens L, Robbens E, Van Wassenhove E, Clement DL. Incidence of arrhythmias after atrial or dual-chamber pacemaker implantation. Eur Heart J. 1989;10(2):102–7.

Skanes AC, Krahn AD, Yee R, Klein GJ, Connolly SJ, Kerr CR, et al. Progression to chronic atrial fibrillation after pacing: The Canadian Trial Of Physiologic Pacing. J Am Coll Cardiol. 2001;38(1):167–72. https://doi.org/10.1016/S0735-1097(01)01326-2

Connolly SJ, Kerr CR, Gent M, Roberts RS, Yusuf S, Gillis AM, et al. Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators. N Engl J Med. 2000;342(19):1385–91.

Andersen KK, Andersen ZJ, Olsen TS. Age- and gender-specific prevalence of cardiovascular risk factors in 40 102 patients with first-ever ischemic stroke: A Nationwide Danish Study. Stroke. 2010;41(12):2768–74.

Grimm W, Langenfeld H, Maisch B, Kochsiek K. Symptoms, cardiovascular risk profile and spontaneous ECG in paced patients: A five-year follow-up study. PACE - Pacing Clin Electrophysiol. 1990;13(12 II):2086–90.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2025 Hussein Murad Muhamad

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Gomal Medical College, Daraban Road, Dera Ismail Khan, Pakistan

ISSN: 1819-7973, e-ISSN: 1997-2067

Website: https://www.gmcdikhan.edu.pk

Phone: +92-966-747373

Scimago Journal & Country Rank