DETERMINATION OF ASSOCIATION BETWEEN KERATOCONJUNCTIVITIS SICCA AND HELICOBACTER PYLORI INFECTIONS IN MIDDLE AGED ADULTS: CROSS SECTIONAL STUDY

Dania Bahaulddin Ibrahim; Suhaib Khalid Ibrahim; Sarah Anwer Jasim

doi:10.46903/gjms/23.1.Special.1846

DETERMINATION OF ASSOCIATION BETWEEN KERATOCONJUNCTIVITIS SICCA AND HELICOBACTER PYLORI INFECTIONS IN MIDDLE AGED ADULTS: CROSS SECTIONAL STUDY

Dania Bahaulddin Ibrahim, Suhaib Khalid Ibrahim, Sarah Anwer Jasim

Abstract

Background: H. pylori can lead to chronic gastritis, peptic ulcers, and gastric adenocarcinoma along with several extra gastric manifestations, such as glaucoma, other dry eye illnesses, and several autoimmune diseases. The purpose of this was to determine the association of patients’ clinical aspects with dry eye disease along with Helicobacter pylori (H. pylori) using serology IgG antibody & urea breath test, which is a non-invasive to find out the relationship of Keratoconjunctivitis sicca and H. pylori chronic gastritis.

Materials & Methods: This cross-sectional, observational study was conducted at Baghdad Teaching Hospital and other medical city hospitals in Baghdad, Iraq, from October to December 2022. One hundred eyes from 50 patients were examined using physical assessments and modern techniques to detect various dry eye diseases based on the severity of sicca stages (0–3). Blood samples were collected from all patients to determine serological IgG antibody levels for chronic gastritis diagnosis, along with more specific urea breath tests for H. pylori detection.

Results: patients diagnosed with H. pylori-induced chronic gastritis were positive for serology IgG antibody & urea breath test IN 30 (60%) cases and negative for both tests in 20 (40%) cases from a total of 50 patients. Patients were aged between (40-60) years old with mean age 50, most patients 20(40%) belong to sicca stage 3 suffered from severe dry eye diseases along with most prevalent investigated 14(28%) positive chronic gastritis caused by H. pylori.

Conclusions: There is a strong relationship between the frequency of dry eye diseases in patients suffering from chronic gastritis caused by the H. pylori bacterium.

Keywords

Conjunctivitis; Dry eye disease; Gastritis; Helicobacter pylori.

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DOI: https://doi.org/10.46903/gjms/23.1.Special.1846