OUTCOME OF EARLY VITRECTOMY IN PATIENTS OF EARLY POST-OPERATIVE CATARACT SURGERY ENDOPHTHALMITIS AFTER CATARACT SURGERY
Abstract
Background: Postoperative endophthalmitis is a vision-threatening complication following cataract surgery. Early vitrectomy has emerged as a promising intervention, especially with advancements in surgical techniques. The objectives of this study were to evaluate the visual outcomes and complication rates of early pars plana vitrectomy (PPV) in patients with acute-onset endophthalmitis after cataract surgery.
Materials & Methods: This quasi-experimental study was conducted at LRBT Hospital, Karachi, from 15 April 2023 to 14 April 2024. A total of 82 patients aged 18–80 years with clinical signs of endophthalmitis within 6 weeks of cataract surgery were included. All patients received intravitreal antibiotics followed by PPV within 48 hours. Visual acuity was assessed at 2 weeks, 3 months, and 6 months. Data were analyzed using SPSS v20, with p<0.05 considered statistically significant.
Results: At presentation, 63.4% had PL+VE vision and 34.1% had HM+VE. Visual acuity improved significantly at each follow-up. By 6 months, 23 patients from the PL+VE group achieved 6/12 vision. Overall, 74.3% showed significant improvement (p<0.0001). Complication rates were low.
Conclusion: Early vitrectomy significantly improves visual outcomes in postoperative endophthalmitis and should be considered early in management, particularly in settings with timely access to vitreoretinal surgery.
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Shao EH, Yates WB, Ho IV, Chang AA, Simunovic MP. Endophthalmitis: changes in presentation, management and the role of early vitrectomy. Ophthalmol Ther. 2021;10(4):877-90. https://doi.org/10.1007/s40123-021-00384-4
Doft B, Nakamura T, Walonker AF. Results of the Endophthalmitis Vitrectomy Study: a randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Arch Ophthalmol. 1995;113(12):1479-96.
Sromicki JW, Stahel M, Blum RA, Rudolph KA, Barthelmes D. Early vitrectomy in endophthalmitis: visual outcomes and complication rates. Ophthalmol Ther. 2025;14(8):2031-42. https://doi.org/10.1007/s40123-025-01196-x
Bilgin B, Güler Ö, Daghan B, Güler M. Results of early vitrectomy for endophthalmitis treatment in a tertiary care hospital. Retina-Vitreus (J Retina-Vitreous). 2025;34(1):1-7.
Kudasiewicz-Kardaszewska AJ, Ozimek MA, Kardaszewska A, Boninska K, Kuhn F, Cisiecki S. Modern Endophthalmitis Control: The Complete Early Vitrectomy for Endophthalmitis (CEVE) Protocol and Surgical Prophylaxis. Cureus. 2025 Sep 3;17(9):e91513. https://doi.org/10.7759/cureus.91513
Michael E, Welch S, Niederer RL. Rapid treatment of endophthalmitis with intravitreal antibiotics is associated with better vision outcomes. Clin Exp Ophthalmol. 2023;51(2):137-43. https://doi.org/10.1111/ceo.14186
Jadoon Z, Shah SP, Bourne R, Dineen B, Khan MA, Gilbert CE, et al.; Pakistan National Eye Survey Study Group. Cataract prevalence, cataract surgical coverage and barriers to uptake of cataract surgical services in Pakistan: the Pakistan National Blindness and Visual Impairment Survey. Br J Ophthalmol. 2007;91(10):1269-73. https://doi.org/10.1136/bjo.2006.106914
Jolley E, Jadoon Z, Khaliq Khan I, Gillani M, Buttan S, Schmidt E. Rapid Assessment of Avoidable Blindness (RAAB) report, Pakistan. Haywards Heath (UK): Sightsavers; 2022. Available from: https://www.sightsavers.org
Pesudovs K, Lansingh VC, Kempen JH, Steinmetz JD, Briant PS, Varma R, et al. Cataract-related blindness and vision impairment in 2020 and trends over time in relation to VISION 2020: the Right to Sight. Invest Ophthalmol Vis Sci. 2021;62(8):3523. https://doi.org/10.1167/iovs.62.8.3523
Siddiqui MA, Hussain SZ, Jeeva I. Post-operative endophthalmitis after immediate sequential bilateral cataract surgery: a retrospective study from Pakistan. J Pak Med Assoc. 2021;71(10):2359-63. https://doi.org/10.47391/JPMA.02-1072
Dib B, Morris RE, Oltmanns MH, Sapp MR, Glover JP, Kuhn F. Complete and early vitrectomy for endophthalmitis after cataract surgery: an alternative treatment paradigm. Clin Ophthalmol. 2020;14:1945-54. https://doi.org/10.2147/OPTH.S252375
Tao BK, Huang RS, Mihalache A, Hwang J, Issa M, Naidu S, et al. Endophthalmitis after bilateral same-day versus unilateral intravitreal injection. Ophthalmol Retina. 2025;9(5):493-5. https://doi.org/10.1016/j.oret.2024.12.004
Vujosevic S, Toma C, Villani E, Nucci P, Brambilla M, Torti E, et al. Longitudinal microvascular and neuronal retinal evaluation in patients with diabetes mellitus types 1 and 2 and good glycemic control. Retina. 2023;43(10):1723-31. https://doi.org/10.1097/IAE.0000000000003667
Panahi P, Mirzakouchaki-Borujeni N, Pourdakan O, Arévalo JF. Early vitrectomy for endophthalmitis: are EVS guidelines still valid? Ophthalmic Res. 2023;66(1):1318-26. https://doi.org/10.1159/000528640
DOI: https://doi.org/10.46903/gjms/23.4.2091
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