FREQUENCY OF HEPATITIS C VIRUS GENOTYPES IN THE NORTH OF PAKISTAN
Abstract
Material & Methods: This descriptive cross-sectional study was conducted from July 2010 to July 2013 at MMT Hospital D. I. Khan and Ibrahimi Hospital & Trust Peshawar, Pakistan. Patients blood samples positive for Anti-HCV were then subjected to PCR for HCV RNA. Genotype determination was done using ROTOR Gene TM. Data was recorded in tables and analyzed by using SPSS version 18.
Results: A total of 537 patients meeting the inclusion criteria, aged between 16 to 65 years, were included in this study, out of which 282 (53.1%) and 255 (46.9%) were males and females respectively. Regarding HCV genotyping; 355 (66.11.%) were type 3a, 14 (2.61%) 3b, 40 (7.45%) type 2a, 5 (0.93%) types 2b, 1a and 1b each, 9 (1.67%) patients mixed types 2a and 3b, 3 (0.56%) were combined 3a and 3b and 101 (18.81%) were un-type able.
Conclusion: Type 3 is the most prevalent HCV genotype in the North of Pakistan followed by type 2. The type 1 genotype is less prevalent in the North as compared to the rest of Pakistan. Because of the more prevalence of type 3 & 2, we can safely recommend shorter durations of antiviral therapy with better viral clearance rates.
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Copyright (c) 2020 Taj Muhammad Khan, Muhammad Tariq Mehr, Hashmat Ullah, Humera Khan, Noor UL Iman
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