MALIGNANT HEMATOLOGICAL DISORDERS ON BONE MARROW ASPIRATION : AN EXPERIENCE FROM TERTIARY CARE HOSPITALS

Abstract

Background: Bone marrow aspiration is a diagnostic test for various hematological malignancies. Present study was designed to determine the frequency of malignant Hematological disorders on bone marrow aspiration.
Material and Methods: This cross sectional study was conducted in the Department of Hematology Khyber Teaching Hospital Peshawar and Qazi Hussain Ahmed Medical Complex Nowshera from Mar 2016 to June 2017. The demographic variables were age, sex and address of the patients, while the research variables were types of hematological disorder. All the variables presented in percentages to find out the frequencies for each variable.
All cases with non-malignant hematological disorders ( Anemias, infections etc) disorders were excluded. Relevant information was recorded on a predesigned proforma prepared in accordance with the objectives of the study.
Results: Out of 102 cases 38% having malignant hematological disorders with age range from 7-76 years. There were 58.21% females and 48.79% males. Majority of the patients were in the age range group 7 to 17 years age 43.59%. Mean age of patient with Standard Deviation was 27±2 years. Mode of age was 27 years. We also received pediatric cases 43% for knowing the cause of various malignant hematological disorders. The frequency of various malignant hematological disorders were; Acute Myeloid Leukemia 33.34%, Acute Lymphocytic Leukemia 30.77%, Chronic Myeloid Leukemia 17.98%, Chronic Lymphocytic Leukemia 7.69% and Multiple Myeloma 10.26%.
Conclusion: Acute Myeloid Leukemia was the most common malignant hematological disorder followed by Acute Lymphocytic Leukemia. AML was most common cause of pancytopenia in our patients among the malignant hematological disorders. Multiple myeloma were also remarkable.