SPECTRUM OF CLINICAL AND HAEMATOLOGICAL FINDINGS IN MALARIA

Jawad Zafar Chaudry, Khalid Mahmood, Muhammad Altaf Hussain, Muhammad Uzair Ilyas Tahirkheli

Abstract


Background: Malaria is commonly associated with various clinical and haematological findings. The study was conducted to evaluate clinical and haematological findings in common types of malaria.
Material & Methods: This descriptive study was conducted in Combined Military Hospital, Dera Ismail Khan, from August 2013 to December 2013. A total of 200 malaria patients confirmed on microscopy of Leishman stained peripheral blood films were included in the study. Complete blood count was carried out using Sysmex KX-21 automated hematology analyzer and thin blood smears were used for microscopy. The research variables were clinical and hematological findings. Data were analyzed by using statistical package for social sciences (SPSS) version 17.0.
Results: Fever was present in all patients, associated with rigors and chills in 143(71.5%) patients and spleen was palpable in 139(69.5%) patients. P. vivax was found in 162(81%) and P. falciparum in 38(19%) patients. Anaemia was associated more with P. falciparum malaria where it was found in 77.8% patients in contrast to 47.3% with P. vivax where it was found in 45.1% patients while 16.7% patients with P. falciparum malaria were lymphocytopenic (p=0.02). Thrombocytopenia was present in 176 (88%) patients without statistically significant difference between the two species.
Conclusion: Fever with rigors, chills and splenomegaly are the main clinical feature. While anaemia, thrombocytopenia and lymphocytopenia are major haematological features in malaria.

Keywords


Malaria; Fever; Anaemia; Thrombocytopenia; Lymphocytopenia.

Full Text:

PDF

References


Bates I, Ekem I. Haematological aspects of tropical diseases. In: Hoffbrand AV, Catovsky D, Tuddenham EGD, editors. Postgraduate Haematology. Massachusetts: Blackwell Publishing; 2005. p. 979-85.

Daneshvar C, Davis TME, Singh JC, Rafaee MZ, Zakaria SK, Divis PCS, et al. Clinical and laboratory features of human Plasmodium knowlesi infection. Clin Infect Dis 2009; 49: 252-60.

Trampuz A, Jereb M, Muzlovic I, Prabhu RM. Clinical review: Severe malaria. Crit Care 2003; 7:315-23.

World Health Organization. World malaria report 2013 [Internet]. Geneva: World Health Organization; 2013 [cited 2014 Mar 4]. Available from: http://www.who.int/malaria/publications/ world_malaria_report_2013/report/en/

Roll back malaria partnership. The global malaria action plan [Internet]. Geneva: Roll back malaria partnership; 2008 [cited 2014 Mar 4]. Available from: http://www.rbm.who.int/gmap/gmap.pdf

Nizamani A, Kalar NA, Khushk IA. Burden of malaria in Sindh, Pakistan: a two years surveillance report. J Liaquat Uni Med Health Sci 2006; 5:76-83.

Bashawri LAM, Mandil AA, Bahnassy AA, Ahmed MA. Malaria: hematological aspects. Ann Saudi Med 2002; 22:372-7.

Lewis SM. Reference ranges and normal values. In: Lewis SM, Bain BJ, Bates I, editors. Dacie and Lewis Practical Haematology. Philadelphia: Elsevier limited; 2006. p.11-21.

Idris M, Sarwar J, Fareed J. Pattern of malarial infection diagnosed at Ayub Teaching Hospital Abbottabad. J Ayub Med Coll 2007; 19: 35-6.

Sheikh AS, Sheikh AA, Sheikh NS, Paracha SM. Endemicity of malaria in Quetta. Pak J Med Res 2005; 44: 41-5.

Haroon H, Fazel PA, Naeem M, Mobin A, Naqvi AH, Makki K. Hide and seek: hematological aspects of malaria – a developing country perspective. J Infect Dev Ctries 2013; 7:273-9.

Khan HU, Khattak AM, Khan MH, Mahsud IU, Shah SH. A study of prevalence of malaria in adult population of DI Khan, Pakistan. Biomedica 2006; 22:99-104.

Lles Rk. Infectious diseases, tropical medicine and sexually transmitted diseases. In: Kumar PJ, Clark ML, editors. Clinical Medicine. Edinburgh: Elsevier limited; 2002. p.21-152.

Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria – correlation with type and severity of malaria. J Assoc Physician I 2004; 52: 615-8.

Jojera AS, Hathila RN, Patel PR, Tailor HJ. Changes in WBC and platelet count in patients with malaria: a hospital based comparative study. Int J Res Med Sci 2013; 1:401-3.

Abro AH, Ustadi AM, Younis NJ, Abdou AS, Hamed DA, Saleh AA. Malaria and hematological changes. Pak J Med Sci 2008; 24:287- 91.

Malik AM, Zaffar N, Ali N, Malik AM, Khan R. Haematological Findings and Endemicity of Malaria in Gadap Region. J Coll Physicians Surg Pak 2010; 20:112-6.

Akhtar S, Gumashta R, Mahore S, Maimoon S. Hematological changes in malaria: a comparative study. IOSR - JPBS 2012; 2:15-9.

Taha K, El-Dein SZ, Idrees M, Makboul G, Baidas G. Hematological changes in malaria: relation to Plasmodium species. Kuwait Med J 2007; 39: 262-7.

Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria - correlation with type and severity of malaria. J Assoc Physician I 2004; 52: 615-8.

Horstmann RD, Dietrich M, Bienzle U, Rasche H. Malaria-induced Thrombocytopenia. Blut 1981; 42:157-64

van Wolfswinkel ME, Jongbloed KV, Melo MM, Wever PC, McCall MB, Koelewijn R, et al. Predictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria. Malar J 2013; 12:101.


Refbacks

  • There are currently no refbacks.


© 2011 Gomal Journal of Medical Sciences