COMPARISON OF EFFECTS OF AMMI VISNAGA EXTRACT AND VERAPAMIL ON CARBACHOL STIMULATED GASTRIC SECRETION IN RABBITS

Subhanullah Jan, Shakirullah Jan, Muhammad Jan

Abstract


Background: Peptic ulcer is mostly produced due to over production of gastric acid. This study was undertaken to compare the effects of extract from fruits of medicinal plant Ammi visnaga which contains natural calcium channel blocker and verapamil on volume and acidity of carbachol induced gastric secretion.
Material & Methods: Thirty rabbits of local breed, weighing 1-1.5 kg were used. The animals were kept fasting for 48 hours, after which the pylorus of each animal was ligated. verapamil 10 mg/kg body weight, Ammi visnaga 500 mg/kg body weight and carbachol 600 mg/kg body weight were administered intraperitoneally.
Results: It was found that verapamil reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with carbachol (p<0.001). The extract also had the same effects. When the difference of mean for verapamil was compared with that of extract, it was found statistically non-significant indicating that the extract has similar effect as that of verapamil on all parameters included in study i.e. free, combined and total acidity.
Conclusion: The extract of Ammi visnaga can be used effectively and safely in the treatment of hyperacidity conditions and peptic ulcer after evaluation in humans.

Keywords


Ammi visnaga; Verapamil; Gastric secretion.

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