Fawad Rahim, Fahim Ullah, Mohammad Haroon, Muhammad Ashfaq, Ayesha Khan Afridi


Background: Acute poisoning including drug overdose is responsible for significant morbidity and mortality. The objectives of this study were to determine the frequency and distribution of acute poisoning in set up of a medical intensive care unit.
Material & Methods: This was a record based, cross-sectional study conducted at Medical ICU of Khyber Teaching Hospital, Peshawar, Pakistan from Feb. 1, 2015 to March 15, 2015. Ninty two patients with acute poisoning admitted to medical ICU between March 2009 and October 2014 were included. The demographic variables were; gender, age in years and marital status. The research variables were; the type of poisons, the number of poisons, route of poisons, mode of poisons, the need for ventilatory, inotropic and renal support, duration of stay, and outcome of patients. Counts and percentages were calculated for the nominal and means and SDs for numeric variables. Chi-square goodness of fit test was applied.
Results: Out of total of 92 patients, 55 (59.8%) were females and 37 (40.2%) were males with female to male ratio of 1.49:1. The mean age of the sample was 26.8±13.9 years. The mean duration of stay for the sample was 3.14±0.52 days. The differences of counts (frequencies) among different attributes of all the ten nominal variables except gender were statistically significant, assuming that all attributes have equal expected counts.
Conclusion: Acute poisoning is a common medical emergency. These patients commonly need ventilatory and inotropic support, and have high mortality rates. Proper triage and timely admission to intensive care unit may improve outcome of these patients.


Poisoning; Organophosphorus; Benzodiazepine; Aluminum phosphide.

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IUPAC. Compendium of chemical terminology. 2nd ed. Oxford, UK: Blackwell Scientific Publications;1997.

Prkacin I, Vujanic S, Dabo N, Palcic I, Naumovski-Mihalic S. Cases of acute poisoning admitted to clinical Hospital Merkur in Zagreb in 1999. Arh Hig Rada Toksikol 2001;52:315-21.

Sorodoc V, Jaba IM, Lionte C, Mungiu OC, Sorodoc L. Epidemiology of acute drug poisoning in a tertiary center from Iasi county, Romania. Hum ExpToxicol 2011;30:1896-1903.

Islambulchilar M, Islambulchilar Z, Kargar-Maher MH. Acute adult poisoning cases admitted to a university hospital in Tabriz, Iran. Hum ExpToxicol 2009 April 1;28:185-90.

Akbaba M, Nazlican E, Demirhindi H, Sütoluk Z, Gökel Y. Etiological and demographical characteristics of acute adult poisoning in Adana, Turkey. Hum ExpToxicol 2007 May 1;26:401-6.

Pombo SD, Fernández JM, Rodelgo GS, Vallés PJC. Epidemiology of acute poisoning: study of 613 cases in the community of Madrid in 1994. Revista Clinica Espanola 1996 March;196:150-6.

Cengiz M, Baysal Z, Ganidagli S, Altindag A. Characteristics of poisoning cases in adult intensive care unit in Sanliurfa, Turkey. Saudi Med J 2006;27:497-502.

Khurram M, Mahmood N. Deliberate self-poisoning: experience at a medical unit. J Pak Med Assoc 2008;58:455-7.

Ozköse Z, Ayoglu F. Etiological and demographical characteristics of acute adult poisoning in Ankara, Turkey Hum ExpToxicol 1999;18:614-8.

Seydaoglu G, Satar S, Alparslan N. Frequency and mortality risk factors of acute adult poisoning in Adana, Turkey, 1997-2002. Mt Sinai J Med 2005;72:393-401.

Qaisar F, Shafi M, Majeed A, Kumar D, Memon A, Memon U. The epidemiology of deliberate self-poisoning presenting at a tertiary care hospital in Hyderabad Sindh, Pakistan. Brit J Med & Med Res 2014;4:1041-8.

Goksu S, Yildirim C, Kocoglu H, Tutak A, Oner U. Characteristics of acute adult poisoning in Gaziantep, Turkey. J Toxicol Clin Toxicol 2002 Jan 1;40:833-7.

Hatzitolios AI, Sion ML, Eleftheriadis NP, Toulis E, Efstratiadis G, Vartzopoulos D, et al. Parasuicidal poisoning treated in a Greek medical ward: epidemiology and clinical experience. Hum Exp Toxicol 2001;20:611-7.

Gunnell D, Eddleston M, Phillips MR, Konradsen F. The global distribution of fatal pesticide self-poisoning: Systematic review. BMC Public Health 2007;7:357.

India. National Crime Records Bureau. Accidental deaths and suicides in India, 2005. New Delhi: Ministry of Home Affairs;2006.

Heijnen H. WHO Bangladesh: International programme on chemical safety;2001.

Khan MM, Reza H. The pattern of suicide in Pakistan. Crisis 2000;21:31-5.

Khan MM, Reza H. Gender differences in nonfatal suicidal behavior in Pakistan: significance of sociocultural factors. Suicide Life Threat Behav 1998;28:62-8.

Fürst S, Habscheid W. Acute poisoning in patients of a medical intensive care unit. Dtsch Med Wochenschr 1993;118:849-53.

Tüfekçi IB, Curgunlu A, Sirin F. Characteristics of acute adult poisoning cases admitted to a university hospital in Istanbul. Hum Exp Toxicol 2004;23:347-51.

Juárez-Aragón G, Castañón-González JA, Pérez-Morales AJ, Montoya Cabrera MA. Clinical and epidemiological characteristics of severe poisoning in an adult population admitted to an intensive care unit. Gac Med Mex 1999;135:669-75.

Akkose S, Bulut M, Armagan E, Cebicci H, Fedakar R. Acute poisoning in adults in the years 1996-2001 treated in the Uludag University Hospital, Marmara Region, Turkey. Clin Toxicol (Phila) 2005;43:105-9.


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