Muhammad Ramzan, Muhammad Bashir, Faiqah Ramzan


Background: Compelling evidence exists that the atherosclerotic process begins in childhood and progresses slowly into adulthood, at which time it leads frequently to coronary heart disease. The present study aims to determine the presence of non fasting hypertriglyceridemia in normal weight and obese primary school children 6-11years.
Material and Methods: A total of 86 school children with 25 normal weight and 61 obese were included in this study. Body-mass-status was determined according to the WHO, 1995 criteria. Non-fasting blood sample was used for lipid screening including Triglyceride (TG); Total Cholesterol (CH), Low Density and High Density Lipoprotein Cholesterol (LDL-C and HDL-C). TG and CH were assessed by enzymatic and LDL-C and HDL-C through direct method.
Results: Mean, for the TG level was observed higher in normal weight girls (181.30 ±15.04 mg/dl) than normal weight boys (141.87 ±37.60 mg/dl). Similar trend was observed in obese children. Mean for the TG concentration in obese girls was assessed higher (238.1 ±95.2 mg/dl) than (204.15 ±55.48 mg/dl) in obese boys. The observed value of 170 mg/dl was calculated as normal for non fasting triglyceride in this study. TG level of 200-400mg was taken as high and a risk factor for cardiovascular disease (CVD). Same is recorded as 1.7% in obese girls and 1.4% in obese boys.
Conclusion: The present study has expressed a significant non-fasting hypertriglyceridemia in obese children especially in obese girls. Non fasting lipid screening is a better option especially for children at risk for CVD and avoids the burden of fasting; is convenient both, for children and parents and that it is less costly and time consuming.


Child; Cardiovascular Diseases; Triglycerides; Cholesterol, LDL; HDL.

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Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010;303:242-9.

Pletcher MJ, Bibbins-Domingo K, Liu K, Sidney S, Lin F, Vittinghoff E, et al. Nonoptimal lipids commonly present in young adults and coronary calcium later in life: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Ann Intern Med 2010;153:137-46.

Mimoun E, Aggoun Y, Pousset M, Dubern B, Bougle D, Girardet JP, et al. Association of arterial stiffness and endothelial dysfunction with metabolic syndrome in obese children. J Pediatr 2008;153:65-70.

Avis HJ, Vissers MN, Stein EA, Wijburg FA, Trip MD, Kastelein JJ, et al. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2007;27:1803-10.

Daniels SR, Greer FR. Lipid screening and cardiovascular health in childhood. Pediatr 2008;122:198-208.

Williams CL, Hayman LL, Daniels SR, Robinson TN, Steinberger J, Paridon S, et al. Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2002;106:143-60.

Steiner MJ, Skinner AC, Perrin EM. Fasting might not be necessary before lipid screening: a nationally representative cross-sectional study. Pediatr 2011;128:463-70.

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-3421.

Devaney BL, Gordon AR, Burghardt JA. Dietary intakes of students. Am J Clin Nutr 1995;61: 205S-212S.

Langsted A, Freiberg JJ, Nordestgaard BG. Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction. Circulation 2008;118:2047-56.

Langsted A, Nordestgaard BG. Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58 434 individuals from the Copenhagen General Population Study. Clin Chem 2011;57:482-9.

Mora S, Rifai N, Buring JE, Ridker PM. Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation 2008;118:993-1001.

Genest J, Frohlich J, Fodor G, McPherson R. Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update. CMAJ 2003;169:921-4.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-52.

Murad MH, Hazem A, Coto-Yglesias F, Dzyubak S, Gupta S, Bancos I, et al. The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis. BMC Endocr Disord 2012;122.

Ford ES, Li C, Zhao G, Pearson WS, Mokdad AH. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med 2009;169:572-8.

Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007;115:450-8.

Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007;298:309-16.

Daugherty A, Lange LG, Sobel BE, Schonfeld G. Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits. J Lipid Res 1985;26:955-63.

Proctor SD, Mamo JC. Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall--evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur J Clin Invest 1998;28:497-503.

Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 1995;854:1-452.

National Cholesterol Education Program (NCEP): Highlights of the Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatr 1992;89:495-501.

Kavey RE, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation 2003;107:1562-6.

Kolovou GD, Mikhailidis DP, Kovar J, Lairon D, Nordestgaard BG, Ooi TC, et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 2011;9:258-70.

Yip PM, Chan MK, Nelken J, Lepage N, Brotea G, Adeli K. Pediatric reference intervals for lipids and apolipoproteins on the VITROS 5,1 FS Chemistry System. Clin Biochem 2006;39:978-83.

Ghandehari H, Kamal-Bahl S, Wong ND. Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004. Am Heart J 2008;156:112-9.

Heiss G, Tamir I, Davis CE, Tyroler HA, Rifkand BM, Schonfeld G, et al. Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study. Circulation 1980;61:302-15.


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