Asmat Shaheen, Salim Khattak, Zahoor Ahmed, Musarrat Jabeen, Rubina Nazli, Roshan Ali


Background: Hypertensive disorder in pregnancy is a major disorder that affects the fetal and maternal prognosis. A newer adipokine, visfatin has been related in the pathogenesis of pregnancy induced hypertension. The aim of this study was to evaluate and compare the serum visfatin and lipid profile in women with pregnancy induced hypertension and normotensive pregnant women.
Materials & Methods: This cross sectional study was done at Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, from January to September, 2015. The patients included were 160 pregnant women with gestational age more than 20 weeks comprising of cases of pregnancy induced hypertension and controls consisting of 74 normal pregnant woman. ELISA method was used to determine serum visfatin level whereas lipid profile was determined by enzymatic colorimetric methods. Data was analyzed using SPSS version19.0.
Results: Statistically significant (p<0.001) serum visfatin levels was found in patients group when compared with controls. When compared with normotensive pregnant women in patients group, the association between serum visfatin level and triglyceride (TG) were significantly higher (p<0.001). A similar trend in results was found between circulating visfatin level and HDL-C and LDL-C in patients upon comparison with controls (p<0.001). The mean difference of the ratio of TC:HDL-C ratio and LDL-C:HDL-C ratio between the patients, and control was statistically significant.
Conclusion: Elevated circulating visfatin level is associated with pregnancy induced hypertension and dyslipidemia in pregnancy.


Visfatin; Hypertension; Pregnancy; Dyslipidemia; Cholesterol.

Full Text:



Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994; 14:1431-7.

Seo JA, Jang ES, Kim BG, Ryu OH, Kim HY, Lee KW, et al. Plasma visfatin levels are positively associated with circulating interleukin-6 in apparently healthy Korean women. Diabetes Res Clin Pract 2008; 79:108-11.

Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308:1592-4.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365:785-99.

Grill S, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, et al. Potential markers of preeclampsia - a review. Reproductive Biol Endocrinol 2009;7:1.

Uotila J, Tuimala R, Aarnio T, Pyykkö K, Ahotupa M. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. BJOG 1993; 100:270-6.

Bergström S, Povey G, Songane F, Ching C. Seasonal incidence of eclampsia and its relationship to meteorological data in Mozambique. J Perinatal Med 1991; 20:153-8.

Shaheen B, Hassan L, Obaid M. Eclampsia, a major cause of maternal and perinatal mortality: a prospective analysis at a tertiary care hospital of Peshawar. J Pak Med Assoc 2003; 53:346-50.

Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307:426-30.

Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, et al. Pre Bcell colony enhancing factor, whose expression is up regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. European J Immunol 2002; 32:3225-34.

Filippatos TD, Randeva HS, Derdemezis CS, Elisaf MS, Mikhailidis DP. Visfatin/PBEF and ath-erosclerosis-related diseases. Cur Vas Pharmacol 2010; 8:12-28.

Fasshauer M, Waldeyer T, Seeger J, Schrey S, Ebert T, Kratzsch J, et al. Serum levels of the adipokine visfatin are increased in pre-eclampsia. Clin Endocrinol 2008; 69:69-73.

Kugiyama K, Doi H, Motoyama T, Soejima H, Misumi K, Kawano H, et al. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 1998; 97:2519-26.

Organization WH. Diet, nutrition, and the prevention of chronic diseases: report of a joint WHO/ FAO expert consultation: Diamond Pocket Books (P) Ltd.; 2003.

De J, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem 2006; 21:165-8.

Tavana Z, Madadi G, Zolghadri J. The relationship between maternal serum visfatin level and hyper-tensive disorders of pregnancy. Int J Gynecol Obstet 2011;15:1528-39.

Belo Ls, Caslake M, Gaffney D, Santos-Silva A, Pereira-Leite Ls, Quintanilha A, et al. Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis 2002; 162:425-32.

An-Na C, Man-Li Y, Jeng-Hsiu H, Pesus C, Shin- Kuo S, Heung-Tat N. Alterations of serum lipid levels and their biological relevances during and after pregnancy. Life Sci 1995; 56:2367-75.

Ognjanovic S, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. Am J Obstet Gynecol 2002; 187:1051-8.

Adegoke O, Iyare E, Gbenebitse S. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women. Nigerian Postgrad Med J 2003; 10:32-6.

Wang P, van Greevenbroek MM, Bouwman FG, Brouwers MC, van der Kallen CJ, Smit E, et al. The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflügers Archiv-European J Physiology 2007;454:971-6.

Smith J, Al-Amri M, Sniderman A, Cianflone K. Visfatin concentration in Asian Indians is correlated with high density lipoprotein cholesterol and apolipoprotein A1. Clin Endocrinol (Oxf) 2006; 65:667-72.

Chen MP, Chung FM, Chang DM, Tsai JCR, Huang HF, Shin SJ, et al. Elevated plasma level of visfatin/ pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metabol 2006; 91:295-9.

Chen CC, Li TC, Li CI, Liu CS, Lin WY, Wu MT, et al. The relationship between visfatin levels and anthropometric and metabolic parameters: association with cholesterol levels in women. Metabolism 2007; 56:1216-20.

Kokia E, Barkai G, Reichman B, Segal P, Goldman B, Mashiach S. Maternal serum lipid profile in pregnancies complicated by hypertensive disorders. J Perinatal Med 1990;18:473-8.


  • There are currently no refbacks.

Copyright (c) 2020 Asmat Shaheen, Salim Khattak, Zahoor Ahmed, Musarrat Jabeen, Rubina Nazli, Roshan Ali

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.