COMPARISON OF URINARY ALBUMIN EXCRETION RATE IN TYPE 1 AND TYPE 2 DIABETICS OF DISTRICT LAHORE

Amir Rehman, Sher Zamir, Sahibzada Saeed Jan, Shaukat Ali

Abstract


Background: The main cause of end-stage renal disease is diabetic nephropathy throughout the world. Renal disease
in diabetics is characterized by increasing rates of urinary albumin excretion, starting from normoalbuminuria,
which progresses to microalbuminuria, macroalbuminuria and ultimately to end-stage renal disease. This study
was conducted to compare the urinary albumin excretion rate in type 1 and type 2 diabetics of district Lahore.
Material & Methods: This comparative cross-sectional study was conducted in the department of Physiology
Sheikh Zayed Medical Complex, Lahore from September 2008 to April 2009. Total 70 subjects were selected for
this study and divided into two groups i.e. known Type 1 and Type 2 diabetics having albuminuria, each having
35 subjects. The urinary albumin excretion in 24 hours urine was measured by Micro-Albumin Quantitative Test
which is a solid phase enzyme-linked immunosorbant assay. The data were analyzed using student t test.
Results: There were a total of 70 subjects, 54 males and 16 females. Out of these, 27 males and 8 females were
type 1 diabetics and 27 males and 8 females were type 2 diabetics. The urinary albumin excretion rate measured
was 181.06±16.98 mg/24 hours in type 1 diabetics and 182.67±27.35 mg/24 hours in Type 2 diabetics. There
was no significant difference between the urinary albumin excretion rate of the two groups (p-value = 1.00).
Conclusion: This study concludes that there is no significant difference between urinary albumin excretion rate
of type 1 and type 2 diabetics.

Keywords


Albuminuria; Microalbuminuria; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Full Text:

PDF

References


Caropeboka LC, Kalalo LP. Description of blood

viscosity from diabetes mellitus outpatients in

endocrine clinic, Aw Sjahranie Hospital. Folia

Medica Indonesiana 2010; 46: 247-52.

American Diabetes Association. Standards of

medical care in diabetes-2013 Diabetes Care

; 36:11-66.

Durrani MYK. Diabetes Mellitus New Vistas, New

Guidelines, Editorial: J Rawal Med Coll 2004;

:1-2.

King K, Jones J, Warthen J. Microvascular and

Macrovascular Complications of Diabetes Mellitus.

Am J Pharm Edu 2005; 69.

Venugopal S, Iyer UM. Risk Factor Analysis and

Prevalence of Microalbuminuria among Type 2

Diabetes Mellitus Subjects. Asian J Exp Biol Sci

; 1: 652-9.

Unnikrishnan R, Rema M, Pradeepa R, Shanthirani

C, Deepa R, Mohan V. Prevalence and Risk

Factors of Diabetic Nephropathy in an Urban

South Indian Population. Diabetes Care 2007;

: 2019-24.

Kramer C, Leitao C, Pinto L, Silveiro S, Gross J,

Canani l. Clinical and Laboratory Profile of Patients

With Type 2 Diabetes With Low Glomerular

Filtration Rate and Normoalbuminuria. Diabetes

Care 2007; 30:1998-2000.

Basi S, Fesler P, Mimran A, Lewis B. Microalbuminuria

in Type 2 Diabetes and Hypertention.

Diabetes Care 2008; 31: 194-201.

Konta T, Hao Z, Takasaki S, Abiko H, Ishikawa

M, Takashashi T, et al. Clinical utility of trace

proteinuria for microalbuminurria screening in

the general population. Clin Exp Nephrol 2007;

:51-5.

Parekh R, Meioni L, Kimmel P, Page J, Knowler W,

Klag M. Reliability of urinary albumin, total protein,

and creatinine assays after prolonged storage:

the family investigation of nephropathy and diabetes.

Clin J Am Soc Nephrol 2007; 2:1156-62.

Parchwani D, Singh SP. Microalbuminuria in

diabetic patients: Prevalence and Putative Risk

Factors. Nat J Com Med 2011; 2:126-9.

Nakhjavani M, Morteza A, Jenab Y, Azam Ghaneei

A, Esteghamati A, Karimi M et al. Gender Difference

in Albuminuria and Ischemic Heart Disease

in Type 2 Diabetes. Clin Med Res 2012; 10:51-6.

Zubair A, Abdul K, Maujid M, Shakir K. Microalbuminuria

in Angiographically Documented

Coronary Heart Disease in Non Diabetic and

Normotensive Individuals. Annals of KEMU 2009;

:111-16.

Ucceferri C,Falasca K, Mancino P, Iorios A,

Vecchiet J. Microalbuminuria and hypertension

in HIV-infected patients: a preliminary study of

telmisartan. Eur Rev Med Pharmacol Sci 2012;

: 491-8.

Derakhshan A, Akhawan M, Karamifar H. Evaluation

of Microalbuminuria 4 to 6 years following

Type-1 Diabetes in Children. Iran J Ped 2007;

:252-6.

Azim W, Azim S, Shafi H, Ahmed K. Diabetic Nephropathy

in Relation to Duration and Severity of

Diabetes Mellitus. Biomedica 2003; 19:33-9.

Greive KA, Osicka TM, Russo LM, Comper WD.

Nephrotic like proteinuria in experimental dibetes.

Am J Nephrol 2003; 23:38-46.

Ladeia AM, Frota CL, Pinho L, Stefanelli E, Adan

L. Endothelial dysfunction is correlated with

microalbuminuria in children with short-duration

type 1 diabetes. Diabetes Care 2005; 28:2048-50.

Araki S, Haneda M, Sugimoto T, Isono M, Isshiki

K, Kashiwagi A, et al. Factors associated with

frequent remission of microalbuminuria in patients

with type 2 diabetes. Diabetes 2005; 54: 2983-7.

Lutale JJK, Thordarson H, Abbas ZG, Vetvik K.

Microalbuminuria among Type 1 and Type 2 diabetic

patients of African origin in Dar Es Salaam,

Tanzania. BMC Nephrol 2007; 8: 2.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Amir Rehman, Sher Zamir, Sahibzada Saeed Jan, Shaukat Ali

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.