Syed Sajid Munir, Nafisa Batool Tahir, Tahir Uddin Qazi


Background: Glucose-6-phosphate dehydrogenase is the commonest enzymopathy in human beings. Acute
hemolytic crisis is the most common presentation of G6PD deficiency but in neonatal period it usually presents
as jaundice. The objective of this study is to determine the frequency of G6PD deficiency in jaundiced neonates.
Material & Methods: This study was conducted at Children Hospital, Pakistan Institute of Medical Sciences,
Islamabad from 27th March 2009 to 27th September 2009. One hundred and sixty-three jaundiced neonates were
included. Screening for G6PD deficiency was done by dye decolorization test, which is semi quantitative, visual
colorimetric assay.
Results: The study included 163 neonates with jaundice. 72.4% were males and 27.6% were females. 16% were
pre-term and 84% were full term babies. The mean age was 4.77±2.80 days. 11(6.7%) were G6PD deficient. 46%
were anemic. Maturity at birth, time of presentation, presence of anemia and hyperbilirubinemia and reticulocytosis
were not significantly different between G6PD deficient and G6PD normal neonates.
Conclusion: Frequency of G6PD defffiency is higher in neonatal hyperbilirubinemia. G6PD assay should be
included in all jaundiced neonates for earlier detection and timely prevention of complication like kernictrus.
KEY WORDS: Neonates; Jaundice; G6PD deficiency.


Neonates; Jaundice; G6PD deficiency.

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Glader BE. Glucose-6-phosphate dehydrogenase deficiency and related disorders of hexose monophosphate shunt and glutathione metabolism. In: Lee GR, Foerster J, Lukens J, et al, editors. Wintrobe’s Clinical Hematology, 10th ed. Baltimore: Williams & Wilkins. p. 1176-90.

Parthasarathy A, Ramachandran P, Thangavelu S. Essential newborn care: Selected Topics in Paediatrics for Practioners. 1st ed. New Delhi: Jaypee Brothers Medical Publishers Ltd; 2004. p. 23-4.

Mohanty D, Mukerjee NB, Colah RB. Glucose-6-phosphate deficiency in India. Indian J Pediatr 2004;71:525-9.

Kaplan M, Hammerman C. Severe neonatal hyperbilirubinemia: A potential complication of glucose-6-phosphate dehygrogenase deficiency. Clin Perinatol 1998; 25:575.

Beutler E. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. Blood 2008; 111:16.

Bienzle U. Glucose-6-phosphate dehydrogenase deficiency. Part 1: Tropical Africa. Clin Haematol 1981; 10:785.

Saldanha PH, Nobrega FG, Maia JC. Distribution and heredity of erythrocyte G6PD activity and electrophoretic variants among different racial groups at Sao Paulo, Brazil. J Med Genet 1969; 6:48.

Siniscalco M. Favism and thalassemia in Sardinia and their relationship to malaria. Nature 1961; 190:1179.

Stamatoyannopoulos G, Panayotopoulos A, Motulsky AG. The distribution of glucose-6-phosphate dehydrogenase deficiency in Greece. Am J Hum Genet 1966; 18:296.

Chan TK, Todd D. Characteristics and distribution of glucose-6-phosphate dehydrogenase-deficient variants in South China. Am J Hum Genet 1972; 24:475.

Panich V. Glucose-6-phosphate dehydrogenase deficiency. Part 2. Tropical Asia. Clin Haematol 1981; 10:800.

Nakatsuji T, Miwa S. Incidence and characteristics of glucose-6-phosphate dehydrogenase variants in Japan. Hum Genet 1979; 51:297.

Heller P, Best WR, Nelson RB, Becktel J. Clinical implications of sickle-cell trait and glucose-6-phosphate dehydrogenase deficiency in hospitalized black male patients. N Engl J Med 1979; 300:1001.

Uddin DE, Dickson LG, Brodine CE. Glucose-6-phosphate dehydrogenase deficiency in military recruits. JAMA 1974; 227:1408.

Tarlov AR, Brewer GJ, Carson PE, Alving AS. Primaquine sensitivity. Glucose-6-phosphate dehydrogenase deficiency: an inborn error of metabolism of medical and biological significance. Arch Intern Med 1962; 109:209.

Lisker R, Linares C, Motulsky AG. Glucose-6-phosphate

dehydrogenase Mexico. A new variant with enzyme deficiency, abnormal mobility, and absence of hemolysis. J Lab Clin Med 1972; 79:788.

Benstein RE. DPIP decolourisation test for G6PD

deficiency. Nature 1962; 194:192.

Zieve L, Hill E, Hanson M. Normal and abnormal

variations and clinical significance of the one-minute and total serum bilirubin determinations. J Lab

Clin Med 1951; 38:446.

Srivatsa A, Bharti B, Shighi SC. Does nimesulide

induce hemolysis in glucose-6-phosphate dehydrogenase

deficiency? Acta Paediatr 2003; 92:637–8.

Siddiqi AA. Incidence and aetiology of neonatal

jaundice in AGA and SGA babies [dissertation]. Karachi: College of Physicians & Surgeons of Pakistan 1998.

Alvi MY, Laeeq A, Khan MA, Iqbal MA. Glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with neonatal jaundice. Pak Paed J 2006; 30:28-33.

Rehman H, Khan MA, Hameed A. Erythrocyte G6PD deficiency and neonatal jaundice. Pak Paed

J 1995; 19: 259-60.

Imran M, Mohammad E. Neonatal jaundice due to G-6PD deficiency. Pak Paed J 1984; 8:126-8.

Ishaq M, Ishaq T, Subhan M, Afridi J. The frequency and age presentation of Glucose-6-phosphate dehydrogenase (G6PD deficiency) in 200 patients of hemolytic anemia. J Postgrad Med Inst 2006; 20:170-3.


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