EFFECT OF ZINC SUPPLEMENTATION ON SERUM FASTING BLOOD SUGAR AND HbA1c IN ADULT DIABETICS ON ORAL HYPOGLYCEMIC AGENTS

Zeba Gul Burki, Mukhtiar Hassan, Samiullah Burki, Waqas Ahmed Farooqui, Aurang Zeb, Sohail Ahmad

Abstract


Background: Studies on humans have shown the beneficial effects of zinc supplementation in patients with diabetes. The objective of this study was to determine the effects of zinc supplementation on fasting blood glucose and HbA1c% in adult diabetic patients on oral hypoglycemic agents.
Material & Methods: This single blinded, randomized control trial was conducted in JPMC, Karachi, Pakistan, from April, 2015 to July, 2015. Sample size was 101 adult diabetic type 2 patients selected through consecutive sampling technique. Subjects were randomly allocated to experimental and control groups. All adults with T2DM on oral hypoglycemic drugs were included. Those having any complications were excluded from the study. Zinc sulphate 20 mg/day plus oral hypoglycemic to intervention group, and placebo plus oral hypoglycemic to control group were given. Demographic variable was ethnicity. Research variables were FBG and HbA1c. Ethnicity had attributes of Pathan, Punjabi and Urdu speakers. Data was analyzed on SPSS. ANOVA test was applied to see the mean difference in experimental and control group, among different ethnicities.
Results: Out of 101 patients 49(48.5%) were males and 52 (51.5%) females. Thirty three subjects (32.2%) were pathan, 32(31.7%) were punjabi and 36(35.6%) were urdu speakers. The mean of difference between experimental and control groups for changes in FBG was 24.03 (p<0.001) in Pathans, 17.11 (p<0.001) in Punjabies and 19.56 (p<0.001) in Urdu speakers. While the mean of difference in HbA1c was 0.67 (p<0.99), 0.6 (p<0.99) and 0.56 (p<0.99) in Pathans, Punjabies and Urdu speakers respectively.
Conclusion: This study indicates significant improvements of Fasting Blood Glucose in zinc supplemented diabetic patients of different ethnic groups.

Keywords


Type 2 diabetes; HbA1c%; Fasting blood glucose (FBG); serum zinc; ethnicity; oral hypoglycemics.

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References


International Diabetes Federation. IDF Diabetes Atlas, 7th edn. Brussels, Belgium: IDF, 2015.

Foster M, Petocz P, Caterson ID, Samman S. Effects of zinc and α-linolenic acid supplementation on glycemia and lipidemia in women with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. J Diab Res Clin Met 2013; 2:3.

Jansen J, Karges W, Rink L. Zinc and diabetes clinical links and molecular mechanisms. J Nutr Biochem 2009;20:399-417.

Taylor CG. Zinc, the pancreas, and diabetes: insights from rodent studies and future directions. Biometals 2005;18:305-12.

Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998;17:109-15.

Marreiro DN, Geloneze B, Tambascia MA, Lerário AC, Halpern A, Cozzolino SM. Effect of zinc supplementation on serum leptin levels and insulin resistance of obese women. Biol Trace Elem Res 2006;112:109-18.

Al-Maroof RA, Al-Sharbatti SS. Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J 2006;27:344-50.

Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr 2001;20:212-8.

Marreiro DN, Martins MD, De Sousa SS, Ibiapina V, Torres S, Pires LV, et al. Urinary excretion of zinc and metabolic control of patients with diabetes type 2. Biol Trace Elem Res 2007;120:42-5

Bennett CM, Guo M, Dharmage SC. HbA1c as a screening tool for detection of type 2 diabetes: a systematic review. Diabetic Med 2007;24:333-43.

Landgraf R. The relationship of postprandial glucose to HbA1c. Diabetes Metab Res Rev 2004;20:S9-12.

American Diabetes Association. Standards of medical care in diabetes-2006. Diabetes care 2006;29:S4.

Simon SF, Taylor CG. Dietary zinc supplementation attenuates hyperglycemia in db/db mice. Exp Biol Med 2001; 226:43-51.

Marchesini G, Bugianesi E, Ronchi M, Flamia R, Thomaseth K, Pacini G. Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism 1998;47:792-8.

Wood RJ, Suter PM, Russell RM. Mineral requirements of elderly people. Am J Clin Nutr 1995;62:493-505.

Nsonwu AC, Usoro CO, Etukudo MH, Usoro IN. Influence of age, gender and duration of diabetes on serum and urine levels of zinc, magnesium, selenium and chromium in type 2 diabetics in Calabar, Nigeria. Turk J Biochem 2006;31:107-4.

Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM, Anderson RA. Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr 2003;22:316-21.

Anand SS, Razak F, Vuksan V, Gerstein HC, Malmberg K, Yi Q, et al. Diagnostic strategies to detect glucose intolerance in a multiethnic population. Diabetes care 2003;26:290-6.

Gunasekara P, Hettiarachchi M, Liyanage C, Lekamwasam S. Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. Diabetes Metab Syndr Obes 2011;4:53-60.

Jindal RM, Taylor RP, Gray DW, Esmeraldo R, Morris PJ. A new method for quantification of islets by measurement of zinc content. Diabetes 1992;41:1056-62.

Hegazi SM, Ahmed SS, Mekkawy AA, Mortagy MS, Abdel-Kadder M. Effect of Zinc Supplementation on Serum Glucose, Insulin, Glucagon, Glucose-6-Phosphatase, and Mineral Levels in Diabetics. J Clin Biochem Nutr 1992;12:209-15.

Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey W. Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5’-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro. Am J Clin Nutr 1997;66:639-42.

Ezaki O. IIb group metal ions (Zn2+, Cd2+, Hg2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes. J Biol Chem 1989;264:16118-22.

Hayee MA, Mohammad QD, Haque A. Diabetic neuropathy and zinc therapy. Bangladesh Med Res Counc Bull 2005;31:62.

Gupta R, Garg VK, Mathur DK, Goyal RK. Oral zinc therapy in diabetic neuropathy. The J Assoc Physicians India 1998;46:939-42.

Raz I, Karsai D, Katz M. The influence of zinc supplementation on glucose homeostasis in NIDDM. Diabetes Res 1989;11:73-9.

Schwartz SL, Fischer JS, Kipnes MS. Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus. Am J Ther 2001;8:247-52.

Oh HM, Yoon JS. Glycemic control of type 2 diabetic patients after short-term zinc supplementation. Nutr Res Pract 2008;2:283-8.


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