EFFECT OF METHIMAZOLE ON SERUM CONCENTRATIONS OF OXIDATIVE STRESS MARKERS IN PATIENTS WITH HYPERTHYROIDISM IN THE POPULATION OF KUTAHYA CITY, TURKEY

Seval Yildiz Sahin, Turkan Pasali Kilit, Fatma Emel Kocak

Abstract


Background: In hyperthyroidism, oxidative stress is produced due to an increase in the production of reactive oxygen species as a result of the hypersecretion of thyroid hormone. The objectives of this study were to determine the effect of methimazole on three oxidative stress markers in patients with hyperthyroidism in the population of Kutahya City, Turkey.

Materials & Methods: This quasi-experimental study was conducted in Faculty of Medicine, Kutahya Health Sciences University, Kutahya, Turkey from August 2020 to September 2021. Thirty newly diagnosed hyperthyroidism patients were included. Methimazole treatment was given to all patients for three months. Two patients were dropped due to allergic reactions. Total antioxidant status (TAS) and total oxidant status (TOS) were measured, and oxidative stress index (OSI) was calculated at the time of diagnosis and after three months of methimazole treatment. All data was analyzed by mean and SD with 95%CI. Three hypotheses were verified by paired samples t test.

Results: In a sample of 30 hyperthyroidism patients, mean TAS level was 1.52 mmol Trolox Eq/L before treatment. It increased significantly to 1.58 with methimazole treatment (p=.013). Mean TOS level was 10.40 μmol H2O2 Eq/L before treatment. It decreased significantly to 6.79 with methimazole treatment (p=<.0001). Mean OSI level was 0.68 arbitrary units before treatment. It decreased significantly to 0.44 with methimazole treatment (p=<.0001).

Conclusion: Methimazole drug treatment for three months for hyperthyroidism increased total antioxidant status, while decreased total oxidant status and oxidative stress index in population of Kutahya City, Turkey.


Keywords


Hyperthyroidism; Total Oxidant Status; Total Antioxidant Status; Oxidative Stress Index; Methimazole; Oxidative Stress; Graves’ Disease; Goiter; Thyroiditis.

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DOI: https://doi.org/10.46903/gjms/20.03.1063

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