Sabiha Iqbal, Mirza Zeeshan Sikandar, Syed Imran Ali Shah, Tashfeen Ikram, Iram Imran, Shaheena Naz


Background: Obesity is a worldwide medical menace with a huge health-economic burden. Glucose metabolism can be regulated by cellular magnesium in many ways; by mediating secretions of insulin and enabling receptor interaction of insulin. The objective of this study was to determine correlation between serum magnesium levels and insulin resistance in obese male subjects and compares with non-obese male.

Material and Methods: This cross sectional study was conducted at Central Park Medical College from December 2021 to May 2022 on 40 obese and 40 non-obese males. Homeostasis model assessment for insulin resistance (HOMA-IR) index was used for determining insulin resistance and magnesium levels were assessed by using atomic absorption spectrophotometry.

Results: A significantly low serum magnesium level was found in obese subjects as compared to controls (mean ±SD 1.356 ±0.215 vs. 1.79 ±0.267 mg/dl, p<0.0001). A significantly high HOMA-IR index was found in obese group than non-obese group (median (IQR); 3.12(2.65-3.46) vs. 1.61(1.46-1.83; p<0.0001).

Conclusion: The study showed significantly lower serum magnesium level and higher insulin resistance in obese men as compared to non-obese. The study has also shown that serum magnesium is negatively correlated with IR. Lower serum magnesium levels and HOMA-IR indices were observed in obese group as compared to non-obese group.


Obesity; Magnesium; Insulin Resistance HOMA-IR; Diabetes Mellitus.

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