Effect of Vitamin “E” Supplements in Therapy of Chronic Hepatitis C: A Histological Study

Abstract

Background: Chronic Hepatitis C is a major healthcare problem worldwide. Current therapies are alpha interferon used either alone or in combination with ribavirin. Antioxidant approaches have not been investigated sufficiently. The aim of this study was to evaluate the efficacy of vitamin E in combination with interferon and ribavirin in reducing hepatic inflammation and fibrosis.

Material & Methods: This experimental study was conducted at Khyber Teaching Hospital Peshawar, Pakistan, from October 2002 to March 2003. Fourteen male patients suffering from chronic hepatitis C were divided into two groups; In group A interferon and ribavirin combination therapy was given and in group B vitamin E was added. Pre and post treatment percutaneous liver biopsy was taken and examined under light microscopy. Both groups were graded according to Knodell Histology Activity Index numerical scoring system. The slides were scored for grades of necrosis and stages for fibrosis.

Results: It was observed that in vitamin E treated patients the progression of fibrosis was prevented or even reversed. In group A, post-therapeutic mean of Knodell score decreased from 11.00±3.74 to 6.60±1.50 (p<0.02). In group B post-therapeutic mean of Knodell score decreased from 10.5± 4.24 to 4.37± 2.06 (p<0.005). Comparing the post-therapeutic Knodell scores in A and B, it was 6.60 ±1.50 and 4.37 ±2.06 respectively (p<0.05).

Conclusion: Addition of Vitamin E to combination therapy with interferon and ribavirin prevents the progression of fibrosis in chronic hepatitis C patients.