Noor J.T. AL-Musawi, Salim Shamkhi Jaafar, Dunia Abbas Khudhair, Hussam A. Mohammed, Mohammed Alaa Abdulzahra, Lubna Abdulazeem


Background: Leptin and adiponectin are hormones that regulate food intake, energy expenditure, and fat metabolism. Elevated levels of leptin and decreased levels of adiponectin have been associated with adverse cardiovascular outcomes. This research study examines the intricate relationship between hunger hormones and lipid profiles in overweight adults with hypertension.

Materials & Methods: Sample size was 120 patients, ranging in age from 30 to 60 years. Of these patients, 60 were overweight with hypertension, while the other 60 were normal weight hypertensive males. The blood levels of appetite hormones (leptin, adiponectin, and the leptin/ adiponectin ratio) were evaluated and analyzed for their correlation with lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.

Results: The research findings clarify the potential associations between hunger hormones, lipid profiles, and hypertension in overweight individuals. The patient exhibited an elevation in leptin levels and a reduction in adiponectin levels. Additionally, there was a negative association between BMI and adiponectin, and a positive correlation between BMI and leptin, as well as the leptin/adiponectin ratio and lipid profile. Furthermore, there was an inverse link between leptin and adiponectin.

Conclusions: Overweight individuals with hypertension had elevated levels of leptin, triglycerides (TG), cholesterol, very low-density lipoprotein (VLDL), and low-density lipoprotein (LDL). There was a positive correlation between leptin and TG, cholesterol, VLDL, and LDL, whereas there was a negative correlation between adiponectin and the same variables.


Appetite hormone; Lipid profile; Obesity; Hypertension.

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