REVIEW OF MEDICAL DESCRIPTION OF CERVICAL CYTOLOGY

Umbreen Naz, Farhan Sarwar, Muhammad Adnan Sarwar, Muhammad Mudassar Ashraf, Muhammad Shoaib Zafar, Muhammad Waqas Khadam

Abstract


Cervical cancer is a malignant neoplasm of the cervical area or cervix which may present with the vaginal bleeding but symptoms may be absent until the cancer gets in advanced stage. Dysplasia seen on cervical biopsy uses the term cervical intraepithelial neoplasia (CIN) and is grouped into mild (CIN-1), moderate (CIN-2) and severe (CIN-3). The severity of CIN depends upon cellular disorganization, cellular immaturity, increased mitotic activity and nuclear abnormalities. The nuclear atypia, extent of mitotic activity and immature cellular proliferations identifies the degree of dysplasia. Thus, epithelial thickness which shows differentiation is the useful feature in decision about severity of CIN. Treatment of this cancer may be ablative and/ or excision. Cryotherapy is a reasonable treatment of CIN-1 and CIN-2 but not of CIN-3 which is severe cervical carcinoma. Burning the TZ-transformation zone (Electro diathermy) destroys the tissue more effectively than that of cryotherapy but it usually requires general anesthesia, however laser cold coagulations technique requires local anesthesia usually. Laser TZ Excision compromises the fertility. Knife cone biopsy is used as a preferred treatment for removal of abnormal cervical cells. Now the cone biopsy is generally performed using the laser surgery. Early diagnosis of cervical cancer is very necessary for better control and treatment of it. For early phases of cervical carcinoma, the cryotherapy is very reasonable, however in case of late stage of the disease laser methods are used alone or on combination. Therapy will be termed successful if cytology remains negative after at least six months of its treatment.

Keywords


Cervix; Cervical; Cervical Biopsy; Cervical Cancer; Vaginal Bleeding; CIN, Cervical Intraepithelial Neoplasia; Cellular Proliferations; Differentiation; Cryotherapy.

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References


Yarbo CH, Debra W, Barbara HG. Cancer Nursing: Principles and Practices. 7th ed. Jones and Bartlett Publishers: Sudbury; 2011.

Boardman CH, Warner KH. Cervical Cancer. Medscape 2016. [accessed 2019 March 12]. Available at: https://emedicine.medscape.com/article/253513-overview.

Monga A, Dobbs S. Premalignant and malignant disease of the cervix. In: Gynecology by ten teachers. Ed: Kenny LC and Myers JE. 19th ed. London: Arnold; 2011.p.125-33.

Hatch KD, Berek JS. Intraepithelial disease of cervix, vagina and value. In: Berek JS, editor. Novak's Gynecology. 13th ed. London: Williams & Wilkins; 2002. p. 471-505.

Rivlin ME, Martin RW. Carcinoma of cervix. In: Manual of clinical problems in obstetrics and gynecology. 5th ed. Philadelphia: Lippincott William & Wilkins; 2000. p. 429-33.

Storck S. Cervical dysplasia. StatPearls Publishing LLC. [accessed 2019 Jan 12] Available from: adam.about.net/encyclopedia/cervical-dysplasia-series.html

Rashid A, Umbreen N, Adnan S, Muhammad MA, Zahid M, Shaukat HM, et al. Historical perspective of cervical cytology: A review. J Uni Med Dent Col 2017; 8(4):1-6.

Naz U, Abid R, Farhan S, Sarwat A, Muhammad MA, Ahsan S. Association of age groups, parity and socioeconomic status with abnormal pap-smear. J Soc Obstet Gynaecol Pak 2017; 7(4):191-5.

Burd EM. Human Papillomavirus and cervical cancer. Clin Microbiol Rev 2003; 16(1): 1-17. https://doi.org/10.1128/CMR.16.1.1-17.2003

Downey G. Preinvasive disease. In: Luesley DM, Baker PN, editors. An evidence-based text for MRCOG. 2nd ed. London: Arnold; 2010.p. 789-96.

Boyd JA, Hamilton TC, Berchuck A. Oncogenes and tumour suppressor genes. In: Hoskins WJ, Perez CA, Young RC, editors. Principles and practice of gynaecological oncology. 3rd ed. Philadelphia: Williams & Wilkins; 2000.p.103-28.

Piyathilake CJ, Macaluso M, Brill I, Heimburger DC, Partridge EE. Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasia. Nutrition 2007; 23(3): 203-10. https://doi.org/10.1016/j.nut.2006.12.002

Dim CC. Towards improving cervical cancer screening in Nigeria: A review of the basics of cervical neoplasm and cytology 2012; 15(3): 247-52. https://doi.org/10.4103/1119-3077.100615

Pund ER, Neiburgs H, Nettles JB. Preinvasive carcinoma of the cervix uteri: Seven cases in which it was detected by examination of routine endocervical smears. Arch Pathol Lab Med 1947; 44: 571-7.

Souther P. Premalignant disease of lower genital tract. In: Shaw RW, Souther WP, Stanton SL, editors. Gynecology. 2nd ed. London: Churchill Livingstone; 1997.p. 521-40.

Nausheen A, Karim SA. The screening for cervical cancer by Pap smear in hospital based population. Annals ASHKMDC 2004; 9: 544-7.

Shafi MI. Premalignant and malignant disease of cervix. In: Edmonds K, editor. Dewhurst's textbook of obstetrics & gynecology. 7th ed. Oxford: Blackwell; 2007.p. 614-23.

Solomon D, Schiffman M, Taron R. Comparison of three management strategies for the patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst 2004; 93: 293-318. https://doi.org/10.1093/jnci/93.4.293

Bacon JL. Carbon dioxide laser surgery in gynecology. Medscape. [updated 2018 Sep 20, accessed 2019 Jan 12]. Available at: https://emedicine.medscape.com/article/272382-overview

Saha M, Iffat A, Sabera K, Suvash CR, Tapan KS. Loop Electrosurgical excision procedure of the transformation zone: an outpatient procedure. Bang J Obs Gyn 2012; 27(1): 5-8. https://doi.org/10.3329/bjog.v27i1.29906

Manjit SB, Rishu G, Anil KS, Manjit KM. Detection of abnormal cervical cytology in Papanicolaou smears. J Cytol 2012; 29(1): 45-7. https://doi.org/10.4103/0970-9371.93222

Mulazim HB, Kanwal S, Samina Q, Muhammad MM, Shahida N, Samina N. Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix. J Cytol 2012; 29(1): 20-5. https://doi.org/10.4103/0970-9371.93213




DOI: https://doi.org/10.46903/gjms/17.04.1998

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