THE CLINICAL MANIFESTATION AND LABORATORY PARAMETERS OF DENGUE NS1 ANTIGEN POSITIVE PATIENTS IN HYDERABAD, SINDH
Abstract
Background: Dengue is a common human infection spread by mosquitoes, this analysis was carried out to assess the occurrence of Dengue Fever in the district of Hyderabad to evaluate the clinical and hematological aspects.
Materials &Methods: From August 2024 to December 2024, the research was conducted on 120 patients, suffering from dengue fever, confirmed by NS1 antigen positive. Complete blood counts were also done. A detailed history was taken.
Results: Out of these total cases of dengue, 72 cases (60%) were males and 48 (40%) were females. According to age, maximum cases 68 (56.66%) were in 21-40 years. The age range was 13–75 years, and children had a lower infection rate.
Conclusion: Fever is most common symptoms appear in all patients. Leucopenia was the second most common outcome, found in 61.66% of patients, while thrombocytopenia was the most common finding, occurring in 67.5% of cases.
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Zafar H, Bukhari KT, Lodhi GM. Global prevalence of dengue viral infection, its pathogenesis, diagnostic and preventive approaches. Asian J Agri Biol. 2013;1(1):38-42. https://doi.org/10.1371/journal.pntd.0009666
Ahmad S, Aziz MA, Aftab A, Ullah Z, Ahmad MI, Mustan A. Epidemiology of dengue in Pakistan, present prevalence and guidelines for future control. Int J Mosq Res. 2017;4(6):25-32.
Ahmed S, Ali N, Ashraf S, Ilyas M, Tariq W, Chotani RA. Dengue fever outbreak: a clinical management experience. J Coll Physicians Surg Pak. 2008;18(1):8-12.
Yadav SNS. A study of abnormal hematological parameters in dengue fever. Headache. 2018;70:70.
Ishaq N, Ilyas MU, Malik KAM, Rahman Z, Ata N, Murtaza HB. Self Medication Practices in Medical Students of Nishter Medical University; A Cross Sectional Study. 2023. https://doi.org/10.51273/esc23.25131938
Ali L, Gul Z, Ijaz A, Khalid N, Zeb F, Afzal S, et al. An overview of dengue viral infection circulating in Pakistan. Journal of vector borne diseases. 2022;59(2):109-14. DOI: 10.4103/0972-9062.331412
Saleem M, Sheikh A, Nawaz H, Ara G. Strengthening dengue control in Pakistan. Eastern Mediterranean Health Journal. 2023;29(12):921-3. https://doi.org/10.26719/emhj.23.099
Suleman M, Lee H-W, Zaidi SSZ, Alam MM, Nisar N, Aamir UB, et al. Preliminary Seroepidemiological survey of dengue infections in Pakistan, 2009-2014. Infectious diseases of poverty. 2017;6:1-7. DOI 10.1186/s40249-017-0258-6
Waseem S, Ahmed SH, Shaikh TG, Qadar LT, Khalid S, Nimavat N, et al. Mysterious dengue‐like virus: A case report from Pakistan. Clinical Case Reports. 2022;10(7):e6107. https://doi.org/10.1002/ccr3.6107
Khan J, Khan A. Incidence of dengue in 2013: dengue outbreak in District Swat, Khyber Pakhtunkhwa, Pakistan. Inter J of Fauna and Biolo Stud. 2015;2(1):1-7.
Adane T, Getawa S. Coagulation abnormalities in Dengue fever infection: a systematic review and meta-analysis. PLoS neglected tropical diseases. 2021;15(8):e0009666.
Khan TA, Nisar S, Qureshi MM, Israr M, Samiullah M. Dengue fever outbreak in twin cities; a tertiary care center experience. Pakistan Armed Forces Medical Journal. 2021;71(5):1524. doi: https://doi.org/10.51253/pafmj.v71i5.4165
Khan J, Khan I, Ghaffar A, Khalid B. Epidemiological trends and risk factors associated with dengue disease in Pakistan (1980–2014): a systematic literature search and analysis. BMC public health. 2018;18:1-13.
Saara N, Kudchi N, Begum Z. Hematological parameters and aminotransferase changes in dengue infection. International Journal of Clinical and Diagnostic Pathology. 2019;2(1):258-60.
Das S, Abreu C, Harris M, Shrader J, Sarvepalli S. Severe Thrombocytopenia Associated with Dengue Fever: An Evidence‐Based Approach to Management of Thrombocytopenia. Case Reports in Hematology. 2022;2022(1):3358325. https://doi.org/10.1155/2022/3358325
Qureshi JA, Notta NJ, Salahuddin N, Zaman V, Khan JA. An epidemic of Dengue fever in Karachi--associated clinical manifestations. Journal of Pakistan Medical Association. 1997;47(7):178.
Jayadas T, Kumanan T, Arasaratnam V, Gajapathy K, Surendran SN. The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka. BMC research notes. 2019;12:1-5.
Rehman AU, Anwar F, Tayyab M, Haq I, Haq M, Ahmed A, et al. Incidence of dengue fever, serotypes, clinical features, and laboratory markers: a case study of 2019 outbreak at district Shangla, KP, Pakistan. African Health Sciences. 2022;22(1):521-31. https://doi.org/10.4314/ahs.v22i1.61
Khan FZ, Sajjad M, Mansoori H, Qadir H, Siddiqui M, Iqbal S. Evaluation of Specxtrum of Laboratory Hematological Manifestation in Dengue Fever. Liaquat Medical Research Journal. 2022;4(4). https://doi.org/10.38106/LMRJ.2022.4.4-05
Garg A, Garg J, Rao Y, Upadhyay G, Sakhuja S. Prevalence of dengue among clinically suspected febrile episodes at a teaching hospital in North India. J Infect Dis Immun. 2011;3(5):85-9.
Mehboob R, Munir M, Azeem A, Naeem S, Tariq MA, Ahmad FJ. Low platelet count associated with dengue hemorrhagic fever. International Journal of Advances in Chemistry (IJAC). 2013;1(1):29-34.
Arshad I, Malik FA, Hussain A, Shah SA. Dengue fever: Clinico-pathologic correlations and their association with poor outcome. The Professional Medical Journal. 2011;18(01):57-63. https://doi.org/10.29309/TPMJ/2011.18.01.1859
Ghani MH, Humaira M, Khushk IA, Ghouri AA, Memon Y, Memon MA. Dengue Virus Outbreak in the Year 2006 at a Tertiary Care Centre in Sindh. JLUMHS. 2008:71.
DOI: https://doi.org/10.46903/gjms/23.4.Suppl.2022
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