AUTOIMMUNE DISORDERS IN CASES WITH ALOPECIA AREATA PRESENTED TO TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY
Abstract
Background: Alopecia areata (AA) is an autoimmune condition which is recognized for its association with various autoimmune disorders. While previous studies have validated links between AA and autoimmune conditions, the data in our setup remain limited, we conducted this study to assess the frequency of autoimmune disease in patients presenting with AA.
Materials & Methods: A cross-sectional study was conducted from 01-Novemeber-2024 to 01-May-2025 at Department of Dermatology, Hayatabad Medical Complex, Peshawar, in which 117 AA patients were enrolled using non-probability consecutive sampling technique. We assessed the autoimmune diseases like hypothyroidism, vitiligo, atopic dermatitis, diabetes, psoriasis and rheumatoid arthritis. Statistical analysis was conducted by Statistical package for social sciences. We used mean and SD for age and duration of AA. Frequency and percentages were evaluated for demographics and AD. Chi square test was used for assessing association of AD with age and gender, keeping significance level at P ≤ 0.05.
Results: There were 117 patients included in this study. Mean age turned out to be 33.97±8.82 years. There 79 males (67.5%) and 38 females (32.5%). Atopic dermatitis was found in 21 (17.9%) patients. Hypothyroidism and diabetes in 9 (7.7%) patients each. Vitiligo 4 (3.4%). Psoriasis in 3 (2.6%) and rheumatoid arthritis was 2 (1.7%).
Conclusion: We found a notable pattern of autoimmune diseases associated with alopecia areata, thyroid disorders, diabetes and atopic dermatitis emerged as the most frequent conditions.
Keywords
Full Text:
PDFReferences
Raghavan JS, Muhammed K, Fathima S. Epidemiological and clinical characteristics of alopecia areata: an observational study from South India. Int J Res Dermatol. 2018;4(3):313–7. https://doi.org/10.18203/issn.2455-4529
Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol. 2021;61(3):403–23. https://doi.org/10.1007/s12016-021-08883-0
Lee HH, Gwillim E, Patel KR, Hua T, Rastogi S, Ibler E, et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: a systematic review and meta-analysis. J Am Acad Dermatol. 2020;82(3):675–82. https://doi.org/10.1016/j.jaad.2019.08.032
Uzuncakmak TK, Engin B, Serdaroglu S, Tuzun Y. Demographic and clinical features of 1,641 patients with alopecia areata, alopecia totalis, and alopecia universalis: a single-center retrospective study. Skin Appendage Disord. 2021;7(1):8–12. https://doi.org/10.1159/000510880
Jadeja SD, Tobin DJ. Autoantigen discovery in the hair loss disorder, alopecia areata: implication of post-translational modifications. Front Immunol. 2022;13:890027. https://doi.org/10.3389/fimmu.2022.890027
Waśkiel-Burnat A, Osińska M, Salińska A, Blicharz L, Goldust M, Olszewska M, et al. The role of serum Th1, Th2, and Th17 cytokines in patients with alopecia areata: clinical implications. Cells. 2021;10(12):3397. https://doi.org/10.3390/cells10123397
Angum F, Khan T, Kaler J, Siddiqui L, Hussain A. The prevalence of autoimmune disorders in women: a narrative review. Cureus. 2020;12(5):e8094. https://doi.org/10.7759/cureus.8094
Anaya JM, Beltrán S. The autoimmune tautology revisited. J Transl Autoimmun. 2023;7:100204. https://doi.org/10.1016/j.jtauto.2023.100204
Cifuentes RA, Restrepo-Montoya D, Anaya JM. The autoimmune tautology: an in silico approach. Autoimmune Dis. 2012;2012:792106. https://doi.org/10.1155/2012/792106
Mitratza M, Klijs B, Hak AE, Kardaun JW, Kunst AE. Systemic autoimmune disease as a cause of death: mortality burden and comorbidities. Rheumatology (Oxford). 2021;60(3):1321–30. https://doi.org/10.1093/rheumatology/keaa537
Leerunyakul K, Suchonwanit P. Asian hair: a review of structures, properties, and distinctive disorders. Clin Cosmet Investig Dermatol. 2020;13:309–18. https://doi.org/10.2147/CCID.S247390
Salam SU, Rafiq Z, Aziz N, Anwar A. Frequency of alopecia areata with other autoimmune disorders. Prof Med J. 2022;29(2):227–31. https://doi.org/10.29309/TPMJ/2022.29.02.6565
Habib A, Ansari MM, Basra AA, Nazeer H, Ahmed A, Shaheen S. A case-control study to assess the association of alopecia areata with thyroid dysfunction and thyroid autoimmunity. J Ayub Med Coll Abbottabad. 2023;35(4):640–4. https://doi.org/10.55519/JAMC-04-12361
Thomas EA, Kadyan RS. Alopecia areata and autoimmunity: a clinical study. Indian J Dermatol. 2008;53(2):70–4. https://doi.org/10.4103/0019-5154.41650
Puavilai S, Puavilai G, Charuwichitratana S, Sakuntabhai A, Sriprachya-Anunt S. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol. 1994;33(9):632–3. https://doi.org/10.1111/j.1365-4362.1994.tb02921.x
Chanprapaph K, Mahasaksiri T, Kositkuljorn C, Leerunyakul K, Suchonwanit P. Prevalence and risk factors associated with the occurrence of autoimmune diseases in patients with alopecia areata. J Inflamm Res. 2021;14:4881–91. https://doi.org/10.2147/JIR.S331579
Holmes S, Harries M, Macbeth AE, Chiu WS, de Lusignan S, Messenger AG, et al. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study. Clin Exp Dermatol. 2023;48(4):325–31. https://doi.org/10.1093/ced/llac104
DOI: https://doi.org/10.46903/gjms/23.4.Suppl.2039
Refbacks
- There are currently no refbacks.
Copyright (c) 2025 Ghafoor Ullah, Hira Rehman, Tooba Rehman, Marwah Rehman, Filza Amjad, Sidra Shabbir

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Gomal Medical College, Daraban Road, Dera Ismail Khan, Pakistan
ISSN: 1819-7973, e-ISSN: 1997-2067
Website: https://www.gmcdikhan.edu.pk
Phone: +92-966-747373

