DECREASE IN LEVEL OF CA-125 AFTER SURGICAL TREATMENT OF ENDOMETRIOSIS

Abstract

Background: Endometriosis is common gynecological condition of women in reproductive age. The objective of the study was to compare the level of CA-125 in patients with endometriosis before and after surgical treatment.
Material & Methods: This cross-sectional study was conducted in the Department of Gynecology and obstetrics, PIMS, Islamabad, Pakistan from February 2012 to March 2013. Sample size was 100. The sampling technique was consecutive non probability. The demographic variables were age and age group. The research variables were parity and level of CA-125. All baseline investigations, CA125 level and pelvic USG were performed. Percentage and frequency for categorical variables like age group and parity were calculated. Mean ±SD of numeric variables like age and level of CA-125 were calculated. Mean change was calculated in CA-125 levels by using paired sample t-test. All collected data was analyzed by using SPSS version 10.
Results: The mean age of the sample was 29.4±5.5 years. Out of total 100 women 78% of the women were between 26 to 40 years of age, 4% were upto 20 years whereas 5% were above 41 years of age. Out of total 100 study cases, 53% were nulliparous, 10% were primiparous while 37% of the women were found to be multiparous. The pre operative mean CA-125 level was 60.5±46.4 IU/ml while post operatively after 6 weeks it was 27.5±17.5 IU/ml and this difference between pre operative and post operative CA-125 levels was statistically significant(p-value=<0.001).
Conclusion: Level of CA-125 decreases markedly in patients with endometriosis after undergoing operative therapy.