SURFACTANT PROTEIN D LEVELS WITH OBESITY AND TYPE 2 DIABETES MELLITUS

Hend Alkwai; Shimaa Mohammad Aboelnaga; Rania Abdeen Hussain; Fahmida Khatoon

doi:10.46903/gjms/18.01.2080

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About The Authors

Hend Alkwai
College of Medicine, University of Ha’il, Ha’il

Assistant Professor, Departments of Paediatric

Shimaa Mohammad Aboelnaga
College of Medicine, University of Ha’il, Ha’il

Deanship of Preparatory Year

Rania Abdeen Hussain
College of Medicine, University of Ha’il, Ha’il

Assistant Professor, Department of Obstetrics & Gynecology

Fahmida Khatoon
College of Medicine, University of Ha’il, Ha’il

Associate Professor, Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il

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SURFACTANT PROTEIN D LEVELS WITH OBESITY AND TYPE 2 DIABETES MELLITUS

Hend Alkwai, Shimaa Mohammad Aboelnaga, Rania Abdeen Hussain, Fahmida Khatoon

Abstract

Surfactant protein D (SP-D) is an important component of pulmonary innate immunity. It is mainly produced by type 2 alveolar and bronchial epithelial cells, but is also found in extra pulmonary tissues and blood. It acts as a primary host defense against inhaled microorganisms. It also enhances adaptive immunity by activating T cells. SP-D deficiency can lead to upper and lower respiratory tract infections. Obesity has reached global epidemic proportions in both adults and children and is associated with numerous co-morbidities and insulin resistance. Type 2 diabetes & obesity are highly associated with recurrent pulmonary & extra pulmonary infections. The primary objective of this study was to determine the association of serum surfactant protein D levels with obesity and type 2 diabetes mellitus.